The interest in the use of green-mediated synthesis of nanoparticles (NPs) is shown to have increased due to their biocompatibility and reduction of overall production costs. The current study aimed to evaluate a novel nanocomposite (NC) prepared by using a combination of zinc oxide, silver and chitosan with lemon extract as a cross-linking agent and assessed its antimicrobial effectiveness against Enterococcus faecalis (E. faecalis). The NPs and NC were prepared individually using a modification of previously established methods. Ananalys is of the physiochemical properties of the NC was conducted using ultraviolet-visible spectroscopy (UV-Vis) (Shimadzu Corporation, Kyoto, Japan). and transmission electron microscopy (TEM) imaging(HR-TEM; JEOL Ltd., Akishima-shi, Japan. The microbial reduction with this novel NC was evaluated by measuring the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using a tube assay analytic technique. A time-kill assay analysis was conducted to evaluate the kinetic potential against E. faecalis at different time intervals. The novel NC showed a homogenous nanoparticle size under TEM imaging and under UV-Vis established an absorption range of 350–420 nm making it similar to its individual counterparts. The MIC and MIB were measured at 62.5 ± 20 mg/L (p < 0.05) and 250 ± 72 mg/L (p < 0.05), respectively. A time-kill assay analysis for the NC showed 5 h was required to eradicate E. faecalis. Based on the achieved results, it was seen that the novel NC using a combination of silver, zinc oxide and chitosan showed improved antimicrobial action against E. faecalis compared with its individual components under laboratory conditions. A complete eradication of 108 log units of E. faecalis at 250 mg/L occurred after a total of 5 h. These preliminary results establish the use of lemon extract-mediated silver, zinc and chitosan-based NC had an antibacterial effectiveness against E. faecalis similar to the individual counterparts used for its production under laboratory conditions.
Background: This article is a study comparing the two most accepted forms of treatment for abnormal uterine bleeding - levonorgestrol intrauterine treatment and transcervical resection of endometrium, with regards to its acceptability, efficacy, adverse effects and user satisfaction. Aim of this study was to compare the acceptability, efficacy, adverse effects and user satisfaction of LNG-IUS and TCRE for treatment for AUB.Methods: A prospective observational study conducted in SKNMC and GH. Forty-nine women with abnormal uterine bleeding after hysteroscopic evaluation were included in this study; where 17 opted for LNG-IUS; 32 opted for TCRE with bipolar electrode. 15 patients in LNG-IUS group and 28 pts in TCRE group completed follow up. Menstrual pattern, pictorial blood loss assessment chart score, adverse effects, acceptability, satisfaction and reason for discontinuation were recorded at 6 weeks, 6 months and 12 months after the procedure. Prior to LNG-IUS insertion or endometrial ablation, endometrial and cervical pathology were excluded by D and C and cervical smear, respectively. TVUS was used to exclude possible causes of menorrhagia, including myomas and endometrial polyp as well as adnexal pathology. LNG-IUS insertion was performed as an office procedure one day after cessation of menstrual bleeding with a negative urine pregnancy test.Results: Menstrual blood loss reductions in TCRE and LNG-IUS groups were by 85.7% and 87.6% respectively after a year. Amenorrhoea was more common in TCRE group while spotting and systemic effects were more common in LNG-IUS group. Satisfaction and acceptance rates are higher in TCRE group.Conclusions: The TCRE and LNG-IUS are equally effective in reducing bleeding in AUB patients. Acceptance and satisfaction are better with TCRE, as a modality of treatment for AUB.
Background and Aim: Dental caries is a multifactorial, widespread chronic infection of the enamel, or dentin caused by plaque. Susceptible tooth surfaces, saliva, oral micro flora, and dietary carbohydrates are the main factors involved in the development of dental caries. Treatment and prevention management of caries among the population is measured in terms of prevalence and severity of anterior teeth caries. The present study's aim was to determine the prevalence of anterior teeth caries among adults. Methodology: This epidemiological study was conducted on 1276 patients reporting for treatment at the College of Dentistry, Jouf University, Saudi Arabia from January 2021 to July 2021. Detection of carries was carried out as per World Health Organization (WHO). Based on demographic details such as age, gender, occupation, and diet, the prevalence of carious anterior teeth was assessed. All the data was coded and analyzed using SPSS version 24. Results: Out of 1276 patients, male and female patients were 814 (63.8%) and 462 (36.2%) respectively. The incidence of carious anterior teeth was 263 (32.2%) in males whereas 149 (32.3%) in female patients. The overall incidence of carious anterior teeth was 32.25%being prevalent in male patients with an age range from 21 years to 30 years. A significant association was found among carious anterior teeth, age (p<0.05), diet (p<0.05), location (p<0.05), teeth malalignment (p<0.05), and oral hygiene (p<0.05). However, anterior decay had no significant association with gender (p=0.673) and occupation (p=.167). Maxillary central incisors were the commonly affected teeth in most cases. Conclusion: Our study found that the prevalence of carious anterior teeth was 32.25% and Maxillary central incisors were the commonly affected teeth in most cases. A significant association was found among carious anterior teeth, age, location, oral hygiene, diet, and teeth malalignment. But no significant association among carious anterior teeth, occupation, and gender. Keywords: Anterior caries, prevalence, dental caries
Background: Endodontic flare-up signifies pain and/or swelling seen within a few days after an endodontic appointment by patients requiring an emergency. These are undesirable and unwanted as they cause great discomfort to the subjects and stress to the operator due to swelling and pain.Aims: This study aims to determine the flare-up incidence and associated risk factors during endodontic treatment.Methods: The present retrospective study assessed 1000 patients of both genders for endodontic flare-ups. Flare-up cases were patients having swelling or pain within 1-3 days after a root canal appointment and needing an emergency visit for relieving the symptoms. After data recording, it was subjected to statistical analysis to assess related factors, flare-up cause, and incidence rate using Fisher's exact test and chi-square test.Results: In the present study, the incidence rate of flare-ups is 9.4%. The majority of flare-ups were in the molar teeth followed by the anterior teeth and 6.7% (n=30) of the premolar teeth. For the number of canals, it was seen in 13.6% (n=24) of cases with multiple canals, 5.5% (n=12) of cases with two canals, and 9.6% (n=58) of cases with a single canal. In patients with no medical history, flare-ups were significantly less compared to patients with medical history (p<0.001). A significantly higher number of flare-ups were in the teeth having pulp necrosis with periapical lesions with 45.9% (n=34) (p<0.001).Conclusion: Flare-ups are commonly seen in multiple canal teeth having pulp necrosis with periapical lesions with an associated medical history, with females being more prone to endodontic flare-up cases.
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