Group-selective molecularly imprinted polymers (MIPs) were synthesized from three kinds of sulfonamides (SAs) and three different functional monomers, with those employing sulfamerazine (SMR) and 2-vinylpyridine (2-Vpy) found to be optimal. The BET test, static adsorption and solidphase extraction (SPE) recovery indicate that the MIPs exhibit strong affinity toward SAs in aqueous solution. Therefore they were used for the quantitative analysis of five SAs in wastewater from treatment plants by off-line SPE coupled to reversed-phase HPLC/DAD. The recoveries and relative standard deviation (RSD) of the molecularly imprinted solid-phase extraction (MISPE) method are 84.1-98.6% and 1.5 to 7.4% in wastewater. The limit of detection (LOD) and the enrichment factor (EF) for SAs were 4.09-19.29 ng L À1 and 411-506 respectively. Five SAs analytes were detected in influents, with residues still remaining in effluents in the range of 29.30-1389.80 ng L À1 .
Highly selective molecularly imprinted polymers (MIPs) that absorb sulfonamides (SAs) are prepared using two types of SAs as mixed templates, 2-vinylpyridine as the functional monomer and ethylene glycol dimethacrylate as the crosslinker. The optimum combination of the mixed templates, their adsorption effect and the imprinting mechanism are evaluated based on SPE recoveries of a family of analytes, equilibrium binding, BET surface area analysis and UV. The results indicate that the mixed templates not only optimize the cavities of the MIPs but also improve the MIPs selectivity and adsorption capacity for the target analytes in aqueous solution. Therefore, MIPs are used for the quantitative analysis of SAs in fish farming water using off-line SPE coupled to HPLC/ DAD. The recovery and RSD were 84.16-101.19 and 1.98-7.10%, respectively. Four SAs analytes were detected in four types of water samples in the range of 8.49-74.60 ng L 21 .
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