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Variation of the side chain in tryptophan as exemplified by indoleacrylic acid produces a compound which interferes with the growth-stimulating action of tryptophan (1). In order to determine whether such a variation in structure among amino acids is general in producing antagonistic effects, ^-substituted acrylic acids which have the same diphenyl ether nucleus as thyroxine have been synthesized for testing as possible antithyroid agents.3,5-Diiodo-4-(4'-methoxyphenoxy)cinnamic acid (II, X = I) and 3,5-dibromo-4-(4'-methoxyphenoxy)cinnamic acid (II, X = Br) were prepared by condensing 3,5-diiodo-4-(4'-methoxyphenoxy)benzaldehyde (I, X = I) and 3,5-dibromo-4-(4'-methoxyphenoxy)benzaldehyde (I, X = Br) (2) with malonic acid in the presence of pyridine and piperidine. SUMMARY 1. 3,5-Diiodo-4-[4'-hydroxy-3',5'-diiodophenoxy]cinnamic acid and related compounds have been prepared for testing as possible antithyroid agents.2. Ultraviolet absorption data and polarographic data are presented as proof for the unsaturation in this compound.