We have investigated 3‐substituted‐2‐phenylimidazo[2,1‐b]benzothiazole derivatives and herein we have discussed their pharmaceutical activities. We found that some 2‐phenyl‐5,6,7,8‐tetrahydroimidazo[2,1‐b]‐benzothiazoles could overcome multidrug resistance for tumor cells. Among them, 2‐phenyl‐3‐(N‐methyl‐3‐piperidyl)carbonylammomiinomemyl‐5,6,7,8‐tetrahydVoimidazo[2,1‐b]benzothiazole [N276‐12] demonstrated the most potent activity for overcoming multidrug resistance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.