Newly synthesized dihydropyridine derivatives as modulators of P-Glycoprotein-mediated multidrug resistance

1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets

“…Other authors tested small libraries of 1,4-DHP derivatives, finding that the presence of a pyridyl group at C-3 and C-5 as well as the substitution at C-4 are effective strategies for reducing calcium channel antagonism and increasing MDR inhibition (Fig. (3)) [13,14]. These findings were in agreement with the previous work of Capolongo et al [15] and were confirmed by other investigators (Fig.…”

A new protocol to synthesize 1,4-dihydropyridines by using 3,4,5-trifluorobenzeneboronic acid as a catalyst in ionic liquid: synthesis of novel 4-(3-carboxyl-1H-pyrazol-4-yl)-1,4-dihydropyridines

“…5,6 Among the possible resistance modifiers, the dihydropyridines (DHPs), calcium antagonists, have been studied extensively as the analogue of verapamil (VP) 1. 7 The finding that the enantiomer of verapamil and nigludipine lacks calcium antagonistic activity but still has MDR reversal activity indicated that the MDR reversal activity is independent of the calcium antagonistic activity. 8,9 It was proposed by Tanabe et al that NIK-250, 2 which possess a heterocyclic ring at the 4-postion can overcome MDR and has moderate calcium antagonistic activity in vitro without optical resolution.…”

An efficient one-pot synthesis of polyhydroquinoline derivatives via Hantzsch condensation using heterogeneous catalyst under solvent-free conditions

“…[4][5] Among the possible resistance modifiers, the dihydropyridines, calcium antagonists, have been studied extensively as the analogue of verapamil. 6 Furthermore, the photocatalytic oxidation of these compounds to pyridines has been intensively investigated. 7 Relatively speaking 1,4-dihydropyridine derivatives combined with a single ring have been mostly reported.…”