Hydrogen peroxide, a cheap and easily available green oxidant, can not only produce oxygen, but also produce hydroxyl radical by homogenization under the catalysis of metal. Toluene and benzyl halide can be oxidized to benzaldehyde by hydrogen peroxide and participate in the reaction with 2-aminobenzylamine. Through the construction of CÀ N bond, a series of quinazoline derivatives were synthesized. This reaction allows a broad range of substrates as well as good functional group compatibility.
Students' evaluation of teaching is an important part of education evaluation and is currently one of the main means of feedback on university teachers' quality of classroom teaching. However, there are three problems with the current indicator system for students' evaluation of teaching: inappropriate system design, lack of pertinence, and lack of qualitative evaluation. Optimizing the indicator system can help solve the aforementioned problems and thus improve the quality of teaching management, promote the professional development of teachers, thereby enhancing the quality of talent training.
Imidazo[1,2-a] pyridine is one of the pharmaceutically important scaffolds and has been widely studied due to its extensive biological activities. In this work, electrospray ionization tandem mass spectrometry (ESI-MS/MS) in positive mode was used to study the gas-phase fragmentation behavior of a series of 3-phenoxy imidazo[1,2-a] pyridines. Proposed fragmentation pathways were supported by ESI-MS/MS data and computational thermochemistry. Homolytic cleavage of the 3-phenoxy C-O bond was the characteristic fragmentation of 3-phenoxy imidazo [1,2-a] pyridines. The eliminations of the one substituted phenoxy radical and CO produced other diagnostic ions for 3-phenoxy imidazo [1,2-a] pyridines, which were useful to identify the 3-phenoxy group and imidazo [1,2-a] pyridine scaffold. The results contribute to the further understanding of the gas-phase fragmentation of 3-phenoxy imidazo [1,2-a] pyridines and the identification of other analogs using tandem mass spectrometry techniques.
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