H₂O₂‐Promoted Inter‐ and Intramolecular C−N Bond Formation: Synthesis of Quinazoline Derivatives

Abstract

Hydrogen peroxide, a cheap and easily available green oxidant, can not only produce oxygen, but also produce hydroxyl radical by homogenization under the catalysis of metal. Toluene and benzyl halide can be oxidized to benzaldehyde by hydrogen peroxide and participate in the reaction with 2-aminobenzylamine. Through the construction of CÀ N bond, a series of quinazoline derivatives were synthesized. This reaction allows a broad range of substrates as well as good functional group compatibility.

I2/H2O2 mediated synthesis and photophysical properties of imidazole-fused heterocycles via [4+1] cyclization approach

“…Meanwhile, H2O2mediated [4+1] cycloadditions under metal-free are uncommon. In this regard, only examples of [5+1] cycloadditions have been reported independently, including the synthesis of quinazoline derivatives by Yang et al [28] and our group [29].…”