A ligand free, Pd-nanoparticle catalyzed synthesis of bis(heterocyclyl)methane derivatives is described herein. The advantages of this method lie in its simplicity, cost effectiveness and environmentally friendliness. The process is very green, as water is exploited as the reaction medium.
Hydroxy coumarin (I), indole (IV), dimedone (VI), and pyrazole (VIII) react with various aromatic aldehydes (II) in the presence of in situ generated palladium nanoparticles giving the title compounds in high yields.
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