A transition metal-free and efficient synthesis of fused azapolycycles via multicomponent reaction has been developed from mucohalic acid as C3 synthon. The reaction promoted by simple inorganic base K2CO3 gives...

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As an important kind of synthons, thiosulfonates can react with alkynes, alkenes, aldehydes, and halogenated hydrocarbons to synthesize thioethers and sulfones. At the same time, some thiosulfonate compounds have anti-viral and anti-fungal bioactivities. The synthesis of thiosulfonates and their applications in organic synthesis have been under the spotlight. Thus, according to different types of catalysts and new progress in green chemistry, the synthesis progress of thiosulfonates is summarized. On the other hand, according to the types of reactants and reaction types, the application progress of thiosulfonates in organic synthesis is reviewed. In the future, among the researches on the construction of new sulfides with thiosulfonates, various difunctionalization reactions are still promising directions. Keywords thiosulfonate; green chemistry; C-S bond formation; photocatalysis; radical reaction; difunctionalization reaction 含硫有机化合物广泛出现在天然产物 [1] 、合成药 物 [2] 、 荧光探针 [3] 等分子中, 在诸多领域都有着十分广泛 的应用 [4] . 硫代磺酸酯是一种特殊的硫化物, 它包含一 个氧化态为 II 的硫原子和另一个氧化态为 VI 的硫原子, 这使它们能够与亲核试剂和亲电试剂反应 [5] . 硫代磺酸 酯不仅可作为有机合成的合成子或者中间体 [6] , 而且具 有良好的生物活性, 如抗病毒、抗真菌、抗寄生虫等作 用 [7] . 因此, 硫代磺酸酯的制备与其在有机合成方法学 中的应用备受人们关注 [8][9] . 鉴于此, 本文以不同的催化 剂与绿色化学新进展为依据, 总结了常见的硫代磺酸酯 的合成策略; 同时, 以反应物种类及其反应类型为依据, 重点对近年来硫代磺酸酯在有机合成上的应用进行了 文献综述.

A facile route for the synthesis of benzodisulfide heterocyclic compounds via a NaHCO3‐promoted three‐component reaction between 2‐halophenylacetic acids, elemental sulfur (S8) and amines under metal‐free conditions has been demonstrated. This transformation from available starting materials shows good functional group tolerance, and the target compounds can be derivatized for further application.