Background: Oral lichen planus (OLP) is a chronic mucocutaneous disease. The cause of oral lichen planus is not well known and the successful management of OLP is still difficult to achieve. Aim:The aim of this randomized clinical trial was to compare the therapeutic effects of triamcinolone acetonide (TA) preparation versus topical 50% coconut cream preparation in the management of atrophic OLP.Methods: 20 patients who had atrophic OLP were selected and randomly divided into two equal groups. (Group I) received topical 50% coconut cream, and (Group II) received topical 0.1% triamcinolone for a period of 4 weeks. Patients were evaluated at baseline before treatment and on days 14, 21 and 28. The following parameters were evaluated; visual analogue scale (VAS) score, degree of erythema and size of erosive area. Results:Our results showed a statistically significant reduction in both groups with a 64.1% reduction in VAS score and 68.5% reduction is the lesion size in the coconut group compared to 74.7% and 77% in the VAS and lesion size in the 0.1% TA group respectively. After 28 days follow up period there was a statistically significant difference between both groups.Conclusion: 50% coconut cream showed a significant reduction in the VAS, degree of erythema and lesion size with no signs of toxicity nor side effects informed during the treatment or follow-up period, thus proving to be a safe and promising medication for OLP.
Background: Immediate post extraction implants are currently widely used; with this surgical technique a dental implant is placed after extraction of teeth in a fresh socket without waiting for any bone or soft tissue healing to reduce the treatment periods. Melatonin is physiologically existing in saliva, and it was found to influence both bone regeneration and fibroblast activation as well as hyaluronic acid which distributed widely throughout neural, connective, and epithelial tissues. Aim:The aim of the present study was to evaluate the effect of topically delivered melatonin gel and hyaluronic acid on dental implants placed into fresh extraction sockets clinically and radiographically. Subjects and Methods:Patients were eligible for the present study if they needed one immediate implant placement (IIP) replacing a tooth to be extracted within the maxillary premolar area. Thirty two adult patients were randomly allocated into four equal groups Group (A): Each patient in this group received immediate implant placement (IIP) with no filling material around the implant .Group (B) : Each patient in this group received IIP simultaneously with topical hyaluronic acid as a filling material into bone gaps around implant .Group (C) : Each patient in this group received IIP with topical melatonin gel plus topical hyaluronic acid to fill the bone gaps around implant .Group (D) : Each patient in this group received IIP with melatonin gel to fill the bone gaps around implant . Clinical and radiographic assessments were performed before IIP (baseline) and 6 months after implant placement. Clinical assessment includes bleeding index (BI), gingival index (GI) and probing depth (PD) while the radiographic assessment were performed using CBCT. Results:The results of this present study showed that local delivery of 1.2% hyaluronic acid and melatonin gel improve the clinical parameters around immediate implants but did not prevent bone loss as assessed by cone beam computed tomography analysis (CBCT). Conclusions:The short term follow up of 6 months of IIP in the maxillary premolar area showed successful clinical outcomes as assessed by clinical parameters and CBCT. IIP with or without simultaneous topical melatonin gel application and hyaluronic acid in the gap distance around the immediate implants did not prevent bone loss.
Objective: Recurrent aphthous ulceration (RAU) is a common condition , Different treatment modalities have been suggested to either eradicate or reduce the duration of ulcer recurrences . Aim of this research was to determine the effectiveness of topically applied 0.5% avocado gel in the treatment of (RAU) .Subjects and method: Sixty patients in the ulcerative stage of RAU were divided at random among two groups . Group I: Patients received topical 0.5% avocado gel three times daily for seven days. GroupII : Patients received topical placebo gel three times daily for seven days. The patients were examined at the time of initial visit before treatment administration and on the fourth and the seventh day of treatment. Results : The results showed that topical 0.5% avocado gel were more effective than placebo gel in the management of minor recurrent aphthous RAU ulceration as it reduces the pain after its application more than the placebo gel alone. Patients on 0.5% topical avocado gel therapy revealed less degree of erythema, decrease in ulcer size and healing period than patients on the placebo therapy. Conclusion: Topical avocado gel may be considerd a reasonable treatment of minor RAU as it reduces pain,erythema and ulcers size and accelerates its healing .
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