Extracellular matrix (ECM) not only serves as a support for tumor cell but also regulates cell–cell or cell–matrix cross-talks. Collagens are the most abundant proteins in ECM. Several studies have found that certain collagen genes were overexpressed in gastric cancer (GC) tissues and might serve as potential biomarkers and therapeutic targets in GC patients. However, the expression patterns of all collagen family genes in GC tissue and their functions are still not clear. With RNA sequencing (RNA-Seq) data, microarray data, and corresponding clinical data obtained from TCGA, GTEx, and GEO databases, bioinformatics analyses were performed to investigate the correlation between the expression patterns of collagen family genes and GC progression. We found that quite many of the collagen family genes were overexpressed in GC tissues. The increase in mRNA expression of most of these overexpressed collagen genes happened between T1 and T2 stage, which indicates the significance of collagens in tumor enlargement of GC. Notably, the mRNA expressions of these differentially expressed collagens genes were highly positively correlated. The elevated expression of a large number of collagen genes in early T stage might greatly change the composition and structure organization of ECM, contributing to ECM remodeling in GC progression.
Realization problem of active noise control system is studied in the article. The foundational theory and algorithm of active noise control are introduced, the feed-forward adaptive active noise control (AANC) system is presented, the hardware solution of the system is proposed by selecting TMS320VC5509 DSP as the controller. Using the C language, the active noise realtime control system is realized, based on the FX-LMS algorithm. It's proved that 12dB cancellation on 800Hz is achieved by the experiment.
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