The involvement of collagen family genes in tumor enlargement of gastric cancer

Sun, Hui; Wang, Yufeng; Wang, Shentao; Xie, Yuan; Sun, Kun; Li, Shuai; Cui, Weitong; Wang, Kai

doi:10.1038/s41598-022-25061-0

Cited by 9 publications

(5 citation statements)

References 59 publications

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“…The extracellular matrix (ECM) is a complex network of proteins and other macromolecules that provide structural support and regulate cell behavior. Dysregulation of extracellular matrix organization can lead to various diseases, including fibrotic diseases 26 , pancreatic cancer 27 , gastric cancer 28 , breast cancer 29 , and other cancer types 30 . Furthermore, the enrichment of terms related to the extracellular region underscores the importance of these genes in regulating the cellular microenvironment.…”

Section: Discussionmentioning

confidence: 99%

MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression

Dong,

Zhan,

et al. 2024

Sci Rep

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Cervical cancer is one of the most common gynecologic malignancies worldwide, necessitating the identification of novel biomarkers and therapeutic targets. This study aimed to investigate the significance of MKRN1 in cervical cancer and explore its potential as a diagnostic marker and therapeutic target. The results indicated that MKRN1 expression was up-regulated in cervical cancer tissues and correlated with advanced tumor stage, higher grade, and poor patient survival. Functional studies demonstrated that targeting MKRN1 effectively inhibited cell proliferation, migration, and invasion, highlighting its critical role in tumor progression and metastasis. Moreover, the knockdown of MKRN1 resulted in altered expression patterns of six transcription factor-encoding genes, revealing its involvement in gene regulation. Co-expression network analysis unveiled complex regulatory mechanisms underlying the effects of MKRN1 knockdown on gene expression. Furthermore, the results suggested that MKRN1 might serve as a diagnostic marker for personalized treatment strategies and a therapeutic target to inhibit tumor growth, metastasis, and overcome drug resistance. The development of MKRN1-targeted interventions might hold promise for advancing personalized medicine approaches in cervical cancer treatment. Further research is warranted to validate these findings, elucidate underlying mechanisms, and translate these insights into improved management and outcomes for cervical cancer patients.

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Section: Discussionmentioning

confidence: 99%

MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression

Dong,

Zhan,

et al. 2024

Sci Rep

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“…The presence of collagen in the GC microenvironment and stromal fibrosis affects GC metastasis [ 23 , 24 ]. The most recent analysis of the mRNA expression of collagen family genes ( COL10A1 and COL11A1 ) in different T stages of GC determined that COL10A1 and COL11A1 mRNA expression was significantly upregulated in the late T stage [ 25 ]. Therefore, collagen is involved in GC progression and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis

et al. 2023

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Background Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. Methods In this study, we elucidated the regulatory role of galectin-1 in GC cell peritoneal metastasis. GC and peritoneal tissues underwent hematoxylin–eosin (HE), immunohistochemical (IHC), and Masson trichrome staining to analyze the difference in galectin-1 expression and peritoneal collagen deposition in different GC clinical stages. The regulatory role of galectin-1 in GC cell adhesion to mesenchymal cells and in collagen expression was determined using HMrSV5 human peritoneal mesothelial cells (HPMCs). Collagen and corresponding mRNA expression were detected with western blotting and reverse transcription PCR, respectively. The promoting effect of galectin-1 on GC peritoneal metastasis was verified in vivo. Collagen deposition and collagen I, collagen III, and fibronectin 1 (FN1) expression in the peritoneum of the animal models were detected by Masson trichrome and IHC staining. Results Galectin-1 and collagen deposition in the peritoneal tissues was correlated with GC clinical staging and were positively correlated. Galectin-1 enhanced the ability of GC cells to adhere to the HMrSV5 cells by promoting collagen I, collagen III, and FN1 expression. The in vivo experiments confirmed that galectin-1 promoted GC peritoneal metastasis by promoting peritoneal collagen deposition. Conclusion Galectin-1-induced peritoneal fibrosis may create a favorable environment for GC cell peritoneal metastasis.

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“…[23] The most recent analysis of the mRNA expression of collagen family genes (COL10A1 and COL11A1) in different T stages of GC determined that COL10A1 and COL11A1 mRNA expression was significantly upregulated in the late T stage. [24] Therefore, collagen is involved in GC progression and metastasis. Notably, we determined that galectin-1 expression in GC tissues was positively correlated with the collagen thickness in the matched peritoneal tissues.…”

Section: Discussionmentioning

confidence: 99%

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis

Shen

Liu

Zhou

et al. 2023

Preprint

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Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis. In this study, we elucidated the regulatory role of galectin-1 in GC cell peritoneal metastasis. GC and peritoneal tissues underwent hematoxylin–eosin (HE), immunohistochemical (IHC), and Masson trichrome staining to analyze the difference in galectin-1 expression and peritoneal collagen deposition in different GC clinical stages. The regulatory role of galectin-1 in GC cell adhesion to mesenchymal cells and in collagen expression was determined using HMrSV5 human peritoneal mesothelial cells (HPMCs). Collagen and corresponding mRNA expression were detected with western blotting and reverse transcription RT-PCR, respectively. The promoting effect of galectin-1 on GC peritoneal metastasis was verified in vivo. Collagen deposition and collagen I, collagen III, and fibronectin 1 (FN1) expression in the peritoneum of the animal models were detected by Masson trichrome and IHC staining. Galectin-1 and collagen deposition in the peritoneal tissues was correlated with GC clinical staging and were positively correlated. Galectin-1 enhanced the ability of GC cells to adhere to the HMrSV5 cells by promoting collagen I, collagen III, and FN1 expression. The in vivo experiments confirmed that galectin-1 promoted GC peritoneal metastasis by promoting peritoneal collagen deposition. To conclude, galectin-1-induced peritoneal fibrosis may create a favorable environment for GC cell peritoneal metastasis.

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The involvement of collagen family genes in tumor enlargement of gastric cancer

Cited by 9 publications

References 59 publications

MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression

MKRN1 regulates the expression profiles and transcription factor activity in HeLa cells inhibition suppresses cervical cancer cell progression

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis

Galectin-1 promotes gastric cancer peritoneal metastasis through peritoneal fibrosis

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