Although abundant works have been developed in mussel-inspired antifouling coatings, most of them suffer from poor chemical stability, especially in a strongly alkaline environment. Herein, we report a robust one-step mussel-inspired method to construct a highly chemical stable and excellent antibiofouling membrane surface coating with a highly efficient codeposition of polydopamine (PDA) with zwitterionic polymer. In the study, PDA and polyethylenimine-quaternized derivative (PEI-S) are codeposited on the surface of poly(ether sulfone) (PES) ultrafiltration membrane in water at room temperature. In contrast to individual PDA coating, the obtained PDA/PEI-S coating exhibits excellent chemical stability even in a strongly alkaline environment owing to the cross-linking and unexpected cation-π interaction between the PEI-S and PDA. Thanks to the introduction of PEI-S, systematic protein adsorption tests and bacteria adhesion experiments demonstrated that the surfaces could prevent bovine serum fibrinogen and lysozyme adsorption and could reduce Gram-positive bacteria S. aureus and Gram-negative bacteria E. coli adhesion. Benefiting from the versatile functionality of PDA, the proposed strategy is not limited to PES membrane surface but also others such as poly(ethylene terephthalate) sheets and commercial polypropylene microfiltration membranes. Overall, this work enriches the exploration of a remarkable coating with enhanced stability and excellent antifouling property via a facile, robust, and material-independent approach to modifying the membrane surface.
Oxidative stress occurs when excess oxidative free radicals are produced in cells, which can overwhelm the normal antioxidant capacity and play an important role in many disease states. Thus, advanced functional materials which can mimic the intracellular antioxidant defense system have a huge potential to become candidates for curing oxidative stress triggered diseases. Herein, a high-performance nanoplatform is developed with a green and mild strategy by combining mimic-enzymatic antioxidant (Fe 3 O 4) and nonenzymatic antioxidant (tannic acid (TA)) for constructing antioxidant defense system (Fe 3 O 4 @ TAn nanoflowers (NFs)). Owing to the excellent peroxidase (POD)-mimic and catalase (CAT)-mimic capacities of Fe 3 O 4 in various conditions, the antioxidant ability of TA and the flower-like morphology, the Fe 3 O 4 @ TAn NFs can effectively scavenge multiple reactive oxygen and nitrogen species. In vitro experiments verify that the Fe 3 O 4 @ TAn NFs demonstrate synergetic antioxidative properties, which can be used to protect blood and cellular components against oxidative damage. Meanwhile, in vivo experiments demonstrate that the Fe 3 O 4 @ TAn NFs exhibit excellent therapeutic effects for systemic inflammation on endotoxemia mice and promote wound healing owing to the excellent antioxidant and anti-inflammatory properties. Thus, this antioxidant defense system expands the toolbox of antioxidative materials and shows potential applications in oxidative stress treatment.
Recently, combining inorganic and organic components to develop a dual-functional surface (antibacterial and antifouling) has resulted in widespread investigations. However, the preparation of the dual-functional surface is limited by the availability of reactive surface chemistries at a material's surface. Herein, owing to the multifunctionality of Tannic acid (TA), we proposed a universal, simple, and environmentally friendly approach to integrate the inorganic (Ag nanoparticles) and organic (zwitterionic) components into the membrane surface to simultaneously endow the surface with antifouling and antibacterial ability, respectively. The Ag nanoparticles (NPs) and zwitterionic polymer were codeposited onto the TA decorated surface. The obtained membrane surface exhibited long-term and robust bactericidal activity. Meanwhile, due to the zwitterionic structure, the membrane could effectively resist bacterial adhesion. Additionally, the proposed strategy could also be employed to construct many kinds of dual-functional surfaces because of the versatile functionality of tannic acid.
Nanofibrous membranes with surface migration of hydrophilic and negatively charged groups were designed for ultrafast water purification and smart dye separation.
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