Potent inhibitors of fucosyltransferases, and glycosyltransferases in general, have been elusive due to the inherent barriers surrounding the family of glycosyltransfer reactions. The problems of weak substrate affinity and low catalytic proficiency of fucosyltransferase was offset by recruiting additional binding features, in this case hydrophobic interactions, to produce a high affinity inhibitor, 24, with Ki = 62 nM. The molecule was identified from a GDP-triazole library of 85 compounds, which was produced by the Cu(I)-catalyzed [2 + 3] cycloaddition reaction between azide and acetylene reactants, followed by in situ screening without product isolation.

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A small-scale continuous flow system, which allows recycling of effluent, has been set up to study the phosphate adsorption ability of air-dried alum sludge from wastewater effluent, and the variation of nitrogen species in wastewater associated with phosphate removal. Initial phosphate removal was rapid, with phosphate levels being reduced by approx. 55% in the first 20 minute of the experiment. The variation of nitrogen species present in the wastewater showed a negative correlation with the concentration of phosphate. Thus, the concentration of ammonia increased from 0 ppm to 16 ppm, while the concentration of nitrate increased from 0 ppm to 98 ppm in the first 20 minutes; nitrite concentrations were found to be insignificant. Very similar phosphate removal patterns and changes in nitrogen species concentrations were exhibited for different batches of alum substrate; the adsorption capacity of spent alum was found to be approx. 0.30–0.33 mg phosphate per 1 g of air-dried spent alum.

A facile anionic cyclization approach toward stereocontrolled synthesis of the hexahydrobenzofuran subunit 3 of avermectin is described. As a model study, treatment of iodo compound 7 with n-BuLi at -100 degrees C effected metal-halogen exchange and subsequent anionic cyclization to afford perhydrobenzofuranone 8. For the total synthesis of subunit 3, compound 9 was dihydroxylated to give diol 10. Protection of the hydroxyl groups of diol 10 gave compound 11. Ketone 11 was then converted into the required enone 12 using Saegusa's protocol. On iodination followed by Luche reduction, enone 12 yielded alpha-iodo allylic alcohol 14, which on alkylation afforded ether 15. Conversion of the ester unit of 15 into a Weinreb amide group followed by anionic cyclization gave enone 17. 1,4-Addition of (MeOCH(2))(2)CuCNLi(2) to enone 17 followed by cleavage of the acetal unit afforded ketone 19. Preferential acetylation of the secondary alcoholic function of 19 afforded compound 20. The stereochemistry of 20 is confirmed by single-crystal X-ray analysis. Elimination of HOAc from 20 gave the crucial olefin 21. Hydrolysis of the acetate unit of 21 followed by protection of the resulting alcoholic function yielded tert-butyldimethylsilyl ether 23. Introduction of a hydroxyl group at the ring junction of 23, using Davis's procedure, finally afforded the hexahydrobenzofuran subunit 3.

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A Pt@TiO2@AAO membrane nanoreactor was fabricated by atomic layer deposition. The photodegradation test of methylene blue demonstrated that the nanoreactor shows efficient photocatalysis performance. It exhibited ~28% photodegradation of methylene blue after ten flow-through cycles, corresponding to about 2.7 × 10(-2) s of contact time of methylene blue with Pt@TiO2 nanotubes.

Three silica-titania thin films with various degrees of molecular homogeneity were synthesized by the sol-gel process with the same precursor formula but different reaction paths. The dried films prepared by a single spin-coating process have a thickness of 500-700 nm and displayed no cracks or pin holes. The transmittances and refractive indices of the samples are >97.8% in the range of 350-1800 nm and 1.62-1.65 at 500 nm, respectively. The in-plane and out-of-plane chemical homogeneities of the films were analyzed by X-ray photoelectron spectroscopy and Auger electron spectroscopy, respectively. For the film with the highest degree of homogeneity, the deviations of O, Si, and Ti atomic contents in both in-plane and out-of-plane directions are less than 1.5%, indicating that the film is highly molecularly homogeneous. It also possesses the highest transparency and the lowest refractive index among the three samples.

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