Background: Monosodium glutamate (MSG) is a commercial food improver and is widely marketed as a flavor enhancer. It is now utilized in many processed foods and by most fast-food chains. Honey is a potent antioxidant that acts in the body against many diseases. Objective: The aim of the current study is to investigate honey's ameliorative effect on kidney damage initiated by monosodium glutamate in adult male rats. Moreover, different polyphenolic compounds in the crude honey were evaluated. Material and methods: Forty adult male albino rats were equally divided into four groups (N=6): The Control group was administered 1 mL of saline daily orally, the MSG group (30 g/kg on diet), the Honey group (2.5 g/kg body weight/day, orally) and Honey/MSG group as the previous for one month. Results: Urea, creatinine, and uric acid were significantly increased in the MSG group and decreased in the honey/MSG group compared to the control group. MSG markedly destructed glomeruli of the kidney and increased the immunoexpressing of nuclear erythroid-related factor 2 (Nrf2) and tumor necrosis factor-alpha (TNF-). Conclusions: Administration of crude honey attenuates and improves the kidney pathological changes induced by MSG.

It has been concluded from several studies that Gum Arabic (GA) offers a protective effect as an anti-inflammatory and antioxidant agent against nephrotoxicity induced by some agents such as adenine and gentamicin. . In this study, the protective and/or treatment effect of GA against Cisplatin-induced acute nephrotoxicity in experimental rats were investigated through several biochemical, histological and immunohistochemical assessment of TGF-beta. Thirty male Wister albino rats were divided randomly into five groups, six rats in each. Group I (negative control), group II (GA) received 6% GA in drinking water, group III (Cisplatin) injected by CP (4.5 mg/kg b.w., i.p.) for two consecutive days, group IV (preventive) pretreated with GA 6% in drinking water daily for 4 weeks before Cisplatin injection and group V (treatment) co-treated by GA with Cisplatin injection (doses as mentioned before). Group III (Cisplatin) showed nephrotoxicity that was manifested by a significant increase in levels of serum Creatinine, urea, and potassium with elevation in kidney MDA level and a decrease in kidney GSH level. In addition, histopathological examination showed severe degeneration and necrosis in kidney tubules. These effects were significantly mitigated by GA administration in both groups IV and V, a result that proves the renoprotective effect of GA.