Background: Rodenticide poisoning is of the major types of poisoning prevalent in India. However this broad category consists of different type of compounds with different mechanisms of toxicity and variable mortality rates. Methods: This study was performed on all cases of rodenticide poisonings admitted to a tertiary care hospital in Mysore between May 2014 and April 2015. Study consisted of 64 subjects. Results: 31 subjects had consumed aluminium phosphide, 18 had consumed Yellow Phosphorus and 12 had consumed Zinc Phosphide while 3 patients had consumed bromadiolone. There were 13 mortalities among the study group out of which 9 were in aluminium phosphide group while 4 were in the yellow phosphorus group. There were no mortalities in cases who had consumed zinc phosphide and bromodiolone. Conclusions: Aluminium phosphide was the most common compound rodenticide consumed and it was associated with increased mortality as compared to other Rodenticide poison.
Background: Isoniazid is the first line agent for the treatment of tuberculosis. Psychosis is a known complication of isoniazid therapy, although infrequent. Case report: One female and two male patients aged 35 years, 55 years and 60 years respectively developed psychosis following isoniazid administration. All the three received 300 mg of isoniazid daily for the management of pulmonary tuberculosis. High dose of isoniazid and low body mass index were identified as the common risk factor for the development of isoniazid associated psychosis. The incidence, possible pathogenesis, risk factors and treatment options are discussed. Conclusion: Isoniazid psychosis is a major complication, which if recognized early can be effectively treated.
Background: Steroids are widely used in modern medicine for the treatment of various ailments. Steroid psychosis is a known complication of steroid therapy, although infrequent. Herein we describe a series of three cases where patients presented with pure psychosis without mood disturbance, which is highly unlikely, following steroid therapy. Cases: Two female and one male patients aged 23 years, 50 years and 80 years respectively developed psychosis following steroid administration. In the first case, oral methylprednisolone (48 mg/day) was used in the management of systemic lupus erythematosus, second case received intravenous dexamethasone (36 mg/day) for the management of bronchopneumonia, while third case had a two day course of intravenous methylprednisolone (120 mg/day) for the treatment of chronic obstructive pulmonary disease. Conclusion: Consistent with the previous studies, female gender and high steroid dose were identified as the common risk factors for the development of steroid psychosis. Steroid psychosis is a major complication, which if recognized early can be effectively treated. Treatment with high dose of steroids should be used cautiously to avoid psychotic adverse reactions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.