Since the reform and opening up in China, rapid urbanization has boosted the development of economy and society, but it has also been confronted by tremendous challenges. Multidisciplinary research has focused on the issue of a national new type of urbanization planning, leading to a transformation of China's urbanization strategy. Further research, however, is needed to explore the theoretical basis for this new approach to urbanization. This paper summarizes the process of development of urbanization in China and describes its specific characteristics, including peri-urbanization, special national conditions, complicated factors, and governance system. China's urbanization makes a great contribution to urbanization on a world scale. Moreover, the literature on the subject demonstrates the significance of urbanization to the discipline of human and economic geography and the scientific connotations of new urbanization, which is people-oriented, harmonious, inclusive, and sustainable. Against a background of humanism, new urbanization represents a transformation from population urbanization to people-oriented urbanization. There are six crucial scientific issues involved: people-oriented urbanization and equalization of basic public services; urbanization with integrated and coordinated urban and rural development; urbanization in the context of resources and environmental carrying capacity and climate change; diverse regional modes; spatial effect and mechanism; and big data and technical innovation. The paper aims to illustrate the theoretical framework of China's new urbanization, providing references for both theoretical research and policy formulation.
Background and purpose The components of ideal cardiovascular health (CVH) metrics have been shown to be associated with non‐alcoholic fatty liver disease (NAFLD). The present study aimed to determine the association between ideal CVH metrics and NAFLD. Methods A total of 10,511 participants (47.26% men) aged 18 to 92 years were selected from the Jidong and Kailuan communities. Ideal CVH was based on 7 ideal CVH metrics: smoking, body mass index (BMI), physical activity, diet, total cholesterol, blood pressure and fasting blood glucose. NAFLD was determined by abdominal ultrasonography. All participants underwent questionnaire assessments and clinical and laboratory examinations. Logistic regression models were used to analyse the relationship of CVH metrics and the number of ideal CVH metrics with NAFLD. Results The prevalence rates of NAFLD by CVH summary score quartiles were 64.38% (2,015/3,130), 50.16% (786/1,567), 33.28% (1,194/3,588) and 20.89% (465/2,226). Participants in the highest quartile showed a lower odds ratio (OR) than those in the lowest quartile (fully adjusted OR: 0.17, 95% CI: 0.17‐0.20, P < 0.001). Similar results were observed in subjects stratified by sex and age (45 years). The ORs were progressively decreased with an increased number of ideal CVH metrics (all P < 0.001). Conclusions NAFLD was significantly associated with both the summary score of CVH metrics and the number of ideal CVH metrics. The combined evaluation of ideal CVH may contribute to the prevention of NAFLD.
An active flavonoid compound rutin was incorporated into a guanosine phenylborate hydrogel (GBR) by a stimuli-responsive borate ester linkage for the treatment of inflammatory bowel disease (IBD). The components and morphology of the drug delivery system were characterized by NMR, UV–vis spectroscopy, and AFM. Rheological measurements revealed the required injectability and self-healing ability, which contributed to its application in rectal administration. The cell assays proved the excellent compatibility and safety of the system, and a possible pathway to form multicellular aggregates. In vitro drug-release studies showed that the hydrogel exhibited good stability in physiological medium, and the drug was almost completely released (more than 90 wt % after 24 h of incubation) in acidic pH and excessive ROS-containing medium, realizing the dual-responsive release of pH/ROS. In vivo activities of the GBR hydrogel showed higher therapeutic efficacy than free rutin in a colitis mice model, and it could significantly inhibit overexpressed inflammatory cytokines, including TNF-α and IL-6. Degradation studies of the hydrogel provided further evidence for the safety of its in vivo application. The work provided a simple strategy to prepare a G-quadruplex drug carrier, which was expected to achieve multi-drug delivery.
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