SummaryThis report concerns the modification of a velour fabric for use in the vascular system. A specially prepared polyurethane was sprayed on the outer surface of this fabric resulting in a negative surface charge. The advantages of this composite were the incorporation of a thin layer of neointima onto the velour surface. Because of its thinness, viability was maintained resulting in a living nonthrombogenic layer at the vascular interface. To prove the efficacy of this material the authors have implanted it into the right atrium, replaced segments of the inferior vena cava, replaced the 4-mm carotid artery, and have used it in the construction of an artificial ventricle device. All performed in a superior fashion with long-term promotion of a viable neointima. It is hoped that the concept of negatively charged velours may be applicable to other phases of biomaterial development.
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