Experience with negatively charged polyurethane‐backed velours

Abstract

SummaryThis report concerns the modification of a velour fabric for use in the vascular system. A specially prepared polyurethane was sprayed on the outer surface of this fabric resulting in a negative surface charge. The advantages of this composite were the incorporation of a thin layer of neointima onto the velour surface. Because of its thinness, viability was maintained resulting in a living nonthrombogenic layer at the vascular interface. To prove the efficacy of this material the authors have implanted it into the right atrium, replaced segments of the inferior vena cava, replaced the 4-mm carotid artery, and have used it in the construction of an artificial ventricle device. All performed in a superior fashion with long-term promotion of a viable neointima. It is hoped that the concept of negatively charged velours may be applicable to other phases of biomaterial development.

Selected topics in biomedical polyurethanes. A review

“…Negatively charged surfaces have less of a tendency for thrombosis than positively charged ones [121][122][123]. This can be easily explained, as under normal conditions the walls of the blood vessels and the platelets have also negative surface charge density.…”

“…This can be easily explained, as under normal conditions the walls of the blood vessels and the platelets have also negative surface charge density. Negatively charged polyurethanes prepared by admixing to the polymer a conductive carbon black (Bioelectric Polyurethane) [121], and/or by the electret effect [122], showed good performance in conctact with blood.…”

“…Incorporation of negative charges in the surface, e.g., by admixing a conductive carbon black [121], using the electret effect [122,131], fixing anionic groups [130] or producing neutral polymers with negative zeta potential [132] is believed to improve the surface-blood compatibility.…”