Background. Treatment of recurrent oropharyngeal cancer is widely thought to have poor outcomes. Justification for treatment, especially in advanced cases, can be difficult. Methods. A systematic search of MEDLINE, Embase, and Cochrane databases was conducted. Included studies reported specific recurrent oropharyngeal cancer survival data.Results. Twenty-two retrospective studies were included. Pooled 3-year overall survival (OS) was 26% (95% confidence interval [CI] 5 22% to 29%; I squared 5 40.7%; p 5 .057). Pooled 5-year OS was 23% (95% CI 5 20% to 27%; I squared 5 73.9%; p 5 .000). Surgical treatment was superior to radiation (5-year OS 26% vs 16%, respectively; p <
Mucoepidermoid carcinomas (MECs) are the most common malignant tumour of the salivary glands. MECs have also been reported to occur in atypical sites. Primary MECs of the thyroid gland are extremely rare, accounting for 0.5% of thyroid malignancies with approximately 48 cases reported in the literature. In most cases, these are low-grade neoplasms with good long-term prognosis. We present the case of a 74-year-old patient with poorly differentiated MEC of the thyroid gland, which behaved aggressively resulting in rapid decline and death of the patient. The exact pathophysiology of the disease remains unclear and there is no consensus on the optimal treatment for this histological subtype. Recognition and diagnosis of this rare neoplasm are important as this can help guide optimal treatment, although in high-grade poorly differentiated cases, treatment options remain limited.
Diagnostic surprises such as melanoma occurring within unusual sites such as submandibular salivary glands are possible. The role of a discerning pathologist with the aid of histochemistry and MDTs is crucial in such circumstances.
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