Poorly differentiated mucoepidermoid carcinoma of the thyroid

Lee, Kristina; Mirza, Omar; Dobbs, Sian; Jayaram, Sharan

doi:10.1136/bcr-2020-236539

Cited by 9 publications

(12 citation statements)

References 12 publications

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“…The tumor's histological composition included epithelial nests with keratinizing cells strewn about, as well as peripherally positioned abnormal basaloid cells and a few cells that contain mucus placed deep into a fibrosclerotic stroma, and all of these features were accompanied by keratinizing cells. a noticeable eosinophilic and lymphoplasmacytic infiltration (7).…”

Section: Discussionmentioning

confidence: 99%

Case Report on Mucoepidermoid Carcinoma of Salivary Gland

Bagwe¹,

Ankar²,

Bhagat³

2022

Journal of Pharmaceutical Negative Results

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Background: The most prevalent kind of salivary gland cancer is mucoepidermoid carcinoma. The main clinical signs of Salivary gland mucoepidermoid carcinoma region is characterized by a lump in the face, neck, discomfort in the mouth, or trouble swallowing. The initial therapy is the surgical removal of the whole tumor .and in the final stage of chemotherapy, radiation therapy is also used. A 43year old male came to the medicine unit with complaints of edema all over the right-side face below the right ear since from 1 year. loss of appetite and disturbance in sleeping patterns. As per the patient’s verbalization, he was apparently all right before a year, and after that, he started to show swelling over the right side of the face and below the right ear for 1 year, for he took treatment in the primary health care center. But after 4 months it was not relieved so again, he went to the private hospital where he has treated with anti-inflammatory medications but still got no relief. Later this swelling was associated with the loss of appetite and disturbance in sleeping patterns now after a year he came to the tertiary care hospital for management. Salivary gland cancer represents 5% of total head and neck tissue cancers. tumors. Small salivary gland tumors, which make up 10% to Approximately Malignant salivary gland neoplasms make up 15% of all cases. The second most frequent cancer type is mucoepidermoid carcinoma. tiny tumors of the salivary glands are common. (12–40 percent worldwide).

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Section: Discussionmentioning

confidence: 99%

Case Report on Mucoepidermoid Carcinoma of Salivary Gland

Bagwe¹,

Ankar²,

Bhagat³

2022

Journal of Pharmaceutical Negative Results

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“…In the thyroid, MECs are rare malignant neoplasms, accounting for 0.5% of thyroid malignancies, with approximately 49 cases reported in the English literature [4]. Patients are aged 10 to 91 years and predominantly female [1].…”

Section: Discussionmentioning

confidence: 99%

“…MECs in the thyroid are generally considered low-grade malignancies and have a favorable prognosis. However, poor prognostic cases of MECs have also been reported [4].…”

Section: Discussionmentioning

confidence: 99%

“…Thyroidal MEC is a rare malignant neoplasm, with only 49 reported cases to date [4]. Commonly, this rare malignant tumor is considered low-grade, but several cases with poor outcomes have also been reported [1,4].…”

Section: Discussionmentioning

confidence: 99%

“…MECs are classified as low-, intermediate-, or high-grade according to their histologic features [3], with most cases being classified as low-grade. However, only 49 MEC cases in the thyroid have been reported in the English literature, with nine cases having a poor prognosis [4].…”

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High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis

Shin

2021

Yeungnam Univ J Med

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Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland, but primary thyroid MEC has rarely been reported and usually has a good prognosis. Herein, I report a case of thyroidal MEC with a poor prognosis in an 82-year-old woman with an anterior neck mass. Ultrasonography and computed tomography revealed a thyroid mass. The patient initially underwent fine-needle aspiration, was diagnosed with malignancy, and underwent a right lobectomy. On gross examination, a 4.0×3.6×2.6 cm-sized ill-defined, unencapsulated, and infiltrative tan to whitish mass with necrosis was identified. Microscopically, epidermoid tumor cell nests or solid sheets were identified. Mucous cells that were positive for periodic acid–Schiff and mucicarmine stains were also identified within epidermoid cell nests. Frequent mitosis and necrosis were observed. Immunohistochemical staining for p40 and p63 was positive, and that for thyroid transcription factor-1 and paired box gene 8 was focally positive. According to the Armed Forces Institute of Pathology grading system for salivary gland MEC, the current case was classified as high-grade MEC. After surgery, the patient suffered from dyspnea due to a remnant neck mass that compressed and obstructed the trachea; therefore, the patient refused further treatment. Thyroidal MECs are considered low-grade with a favorable prognosis, but there are several reported cases of thyroidal MEC with poor prognosis. The current case is a rare presentation of high-grade thyroidal MEC with a poor prognosis.

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