Aims: The aim of the present work to perform phytochemical screening and wound healing activity of different leaf extract of Rhynchosia rothii. Place and Duration of the Study: The present work has been carried out at Oriental University, Indore between the duration of November-2020 to January-2021. Methodology: Rhynchosia rothii dried leaf powder was subjected to continuous extraction with a soxhlet extractor using various organic solvents. Preliminary phytochemical screening with various qualitative chemical tests revealed the presence of Alkaloids, Tannins, Flavonoids, proteins, and mucilage present in Rhynchosia rothii leaf extracts. Wister rats of both sexes weighing 150-200 g were used for experimental purposes. The animals were kept in polypropylene cages at room temperature and with a light/dark cycle of 12:12 hours. All the test extracts at a different dose level and standard were administered topically once daily from day 0 to the day of complete healing or the 21st postoperative day, whichever occurred earlier. Results: A significant increase in wound healing activity was observed in animals treated with alcoholic and aqueous extracts of Rhynchosia rothii leaves at a dose of 200 mg/kg body weight, compared to control treatments. Both methanolic and standard extracts of Rhynchosia rothii (200 mg/kg body weight) showed a dose-dependent increase in the rate of wound contraction. The methanolic extract of Rhynchosia rothii at a dose of 200 mg/kg body weight showed an increase in the percentage of wound contraction from 40.08% to 88.90% from day 3 to 12. The aqueous (standard) extract of Rhynchosia rothii at a dose of 200 mg/kg body weight showed an increase in the percentage of wound contraction from 46.02% to 100% from day 3 to 12. Conclusion: From the previous results it was concluded that the Wound represents a serious health problem, both in terms of morbidity and mortality. Wound healing is a critical response to tissue integrity. Therefore, the wound healing property of Rhynchosia rothii can be attributed to the phytoconstituents present in it, which may be due to its individual or additive effect that accelerates the wound healing process. Since Rhynchosia rothii is grown in abundance in India and rest of other part of world, it could be a fairly good and easily available therapeutic agent due to its naturally occurring tendency for healing wounds as a healer, as well as controlling abnormal healing.
In the twenty-first century, nanotechnology has become cutting-edge technology. It is interdisciplinary and multidisciplinary, covering numerous fields such as medicine, engineering, biology, physics, material sciences, and chemistry. The present work aims to cover the optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots (QDs). Articles were reviewed in English literature reporting the pharmaceutical and bio-pharmaceutical aspects of QDs which were indexed in Scopus, web of science, google scholar and PubMed without applying the year of publication criterion. One significant value of utilizing nanotechnology is that one can alter and control the properties in a genuinely unsurprising way to address explicit applications' issues. In science and biomedicine, the usage of functional nanomaterials has been broadly investigated and has become one of the quick-moving and stimulating research directions. Different types of nanomaterial (silicon nanowires, QDs, carbon nanotubes, nanoparticles of gold/silver) were extensively utilized for biological purposes. Nanomedicine shows numerous advantages in the natural characteristics of targeted drug delivery and therapeutics. For instance, protection of drugs against degradation, improvement in the drug's stability, prolonged circulation time, deceased side effects, and enhanced distribution in tissues. The present review article deals with the quantum dots, their optical properties, method of preparations, surface modifications, bio-conjugation, characterization, stability, and cytotoxicity of quantum dots. The review also discusses various biomedical applications of QDs. The QDs-based bio-nanotechnology will always be in the growing list of unique applications, with progress being made in specialized nanoparticle development, the detection of elegant conjugation methods, and the discovery of new targeting ligands.
In our previous work we have reported wound healing activity of leaves extract of Rhynchosia rothii in which we got excellentactivity. Therefore in present study, the development of Rhynchosia rothii loaded Lycoat RS 720-BSA conjugated polymericnanoparticles and subsequent ointment formulation has been aimed. Maillard Reaction was used to develop the Lycoat RS 720-BSAconjugate. The solvent evaporation approach was used to produce nanoparticles with Rhynchosia rothii loaded on them. Thenanoparticles had a 257nm particle size and exhibited a spherical shape. The zeta potential in the formulation was -22.4 mV.Entrapment efficiency was 88.32% in the enhanced batch. The extracted content of the optimized batch was found to be 78.10%. Acontinuous release pattern was found by the in-vitro diffusion investigation, with 94.24% diffusion after 24 hours. The Rhynchosiarothii extract was created as an absorbent ointment formulation with a pH of 6.80–6.92 and a spread ability of 80.00–110.16 g.cm/s.It also has a distinctive aroma. Ointment containing herbal nanoparticles from the F4 batch has produced positive results. A newmethod of promoting nanoparticles in herbal medication delivery systems is by employing them in nanoparticles and an ointment.From present investigations we concluded that prepared ointment can be used clinically for the treatment of wounds if optimizedfurther using more in vitro and in vivo models along with toxicity predictions.
Over the last few years, interest has been increased in developing innovative drug delivery systems to improve the safety, efficacy and patient compliance. Development of new chemical entity is not only expensive but also time taking process. This is why most of the pharmaceutical companies are now focusing on the development of new and improved drug delivery systems for the existing drugs. One such system is the fast dissolving tablets and films which are gaining popularity now days. These fast dissolving formulations are prepared in such a way that the total time taken by the active pharmaceutical ingredient to disintegrate is very less as compared to other formulations. This technique allows the drug to dissolve at a much faster rate thus reducing the time for the onset of action. These formulations are fast acting and can be administered without water. Therefore, they are very suitable for pediatric and geriatric patients; bed ridden patients; or patients suffering from dysphagia, Parkinson's disease, mucositis, vomiting, migraine, fever, pain etc. Hence these are beneficial for the pediatric and geriatric patients. There are several methods employed for the manufacturing of such dosage forms such as casting, spraying, extrusion etc. the aim of the present investigation is to analyze and review rapidly disintegrating dosage form.
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