The aim of this study is to examine the effects of granisetron on the sensory and motor block and haemodynamic changes resulting from subarachnoid block using hyperbaric bupivacaine. Methods: Forty ASA I and II adult patients undergoing infraumblical surgery under spinal anesthesia were included in this prospective, randomised, double blind study. They wrere randomly divided into two groups.Using computer generated random numbers, patients were allocated to one of two groups: Control Group: Patients of this group received normal saline. Granisetron Group: Patients of this group received 1mg Granisetron. Patients of both groups received heavy 0.5% Bupivacaine intrathecally. Result: All the demographic parameters were comparable.19 patients (67.8%) in saline group while 13 patients (46.4%) in granisetron group had hypotension which was treated with IV ephedrine. Saline group had more than three episodes of hypotension while none of the patients in granisetron group had hypotensive episodes more than two.The maximum cephalad spread of sensory block was similar (P = 0.13).T Patients who received granisetron had significantly faster sensory regression times by two segments from T12 -S1. However motor regression is similar in both group. There were no significant differences between the two groups in haemodynamic variables. Conclusion: IV administration of granisetron, in a dose of 1 mg, before intrathecal bupivacaine results in a faster recovery of sensory block in adult patients. There is also less incidence of hypotension in Granisetron group.
This study was designed to compare different doses of cis-atracurium (2×ED95, 4×ED95, 6×ED95) in regarding onset time, condition of intubation , duration of action, hemodynamic effects, and signs of histamine release. Methods: Sixty ASA I and II adult patients undergoing abdominal surgery under general anesthesia were included in this prospective, randomised, double blind study. Patients were allocated to one of three groups: Group 1: Patients in this group received with initial dose of 0.1 mg/kg (2×ED95) of cis-atracurium. Group 2: Received initial dose of 0.2 mg/kg (4×ED95). Group 3: Received initial dose of 0.3 mg/kg (6×ED95). Result: All the demographic parameters were comparable.There was a statistically significant increase in HR, MABP post intubation when compared to baseline and post injection of 2× ED95 dose of cisatracurium in group 1. Higher doses of cisatracurium (4×ED95 and 6×ED95) showed onset time that was significantly lower than cisatracurium (2×ED95). Regarding the duration of action, higher doses of cisatracurium (4×ED95 and 6×ED95) showed statistically significant longer duration of action than lower doses of cisatracurium. 4×ED95 and 6×ED95 doses of cisatracurium were significantly better than 2×ED95 dose of cisatracurium. Only 6×ED95 dose of cisatracurium was statistically significant with higher percentages of patients with excellent condition of intubation. Conclusion:We can conclude that the higher doses of cisatracurium provide more effective, more rapid neuromuscular blocking with longer duration of action, stable hemodynamic status, and no associated signs of histamine release clinically.
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