Study of intavenous granisetron on haemodynamic changes and motor and sensory blockade in spinal anesthesia with hyperbaric bupivacaine in patient undergoing infraumblical surgery

Abstract

The aim of this study is to examine the effects of granisetron on the sensory and motor block and haemodynamic changes resulting from subarachnoid block using hyperbaric bupivacaine. Methods: Forty ASA I and II adult patients undergoing infraumblical surgery under spinal anesthesia were included in this prospective, randomised, double blind study. They wrere randomly divided into two groups.Using computer generated random numbers, patients were allocated to one of two groups: Control Group: Patients of this group received normal saline. Granisetron Group: Patients of this group received 1mg Granisetron. Patients of both groups received heavy 0.5% Bupivacaine intrathecally. Result: All the demographic parameters were comparable.19 patients (67.8%) in saline group while 13 patients (46.4%) in granisetron group had hypotension which was treated with IV ephedrine. Saline group had more than three episodes of hypotension while none of the patients in granisetron group had hypotensive episodes more than two.The maximum cephalad spread of sensory block was similar (P = 0.13).T Patients who received granisetron had significantly faster sensory regression times by two segments from T12 -S1. However motor regression is similar in both group. There were no significant differences between the two groups in haemodynamic variables. Conclusion: IV administration of granisetron, in a dose of 1 mg, before intrathecal bupivacaine results in a faster recovery of sensory block in adult patients. There is also less incidence of hypotension in Granisetron group.

Efek Pemberian Ondansetron Intravena Terhadap Tekanan Darah Dan Laju Nadi Pasien Bedah Elektif Dengan Anestesi Spinal Di Rsud Raden Mattaher Jambi

“…Dilaporkan, insiden terjadinya hipotensi mencapai 80%. 4 Hipotensi diketahui mencapai 60% pada pasien obstestrik dan 33% pada pasien non obstestrik. 3 Sementara, penelitian lain menyebutkan angka kejadian hipotensi yang disertai bradikardia mencapai 33% pada pasien obstestri dan 13% pada pasien non obstestri.…”

Ondansetron or beta-sitosterol antagonizes inflammatory responses in liver, kidney, lung and heart tissues of irradiated arthritic rats model

“… 30 Ondansetron (O), a 5-HT3 receptor antagonist, is commonly used to prevent and treat nausea and vomiting caused by radiation therapy, chemotherapy, gastroenteritis, and surgery, 31 as well as may also reduce hemodynamic changes caused by spinal anesthesia. 32 Moreover, preliminary data have shown that the intravenous injection of ondansetron has an analgesic effect on neuropathic pain. 33 It was proposed that ondansetron’s ability to reduce inflammation may be mediated by its impact on 5-HT3 receptor pathways.…”