No abstract

No abstract

Recent advances in additive manufacturing make it possible to fabricate periodic lattice structures with complex configurations. However, a proper design strategy to achieve lattice structures with controlled anisotropy is still unavailable. There is an urgent need to fill this knowledge gap in order to develop mechanical metamaterials with prescribed properties. Here we propose two different methodologies to design lattice structures with controlled anisotropy. As examples, we created two new families of lattice structures with isotropic elasticity and cubic symmetric geometry. The findings of this work provide simple and effective strategies for exploring lightweight metamaterials with desired mechanical properties.

The activity of CVT-E002, an aqueous extract containing mainly oligosaccharides and polysaccharides from North American ginseng (Panax quinquefolium), as an immunobooster on murine spleen cells and peritoneal macrophages, was studied in-vitro. CVT-E002 stimulated the proliferation of normal mouse spleen cells, of which the major responding subpopulation was identified as B lymphocytes. CVT-E002 also activated peritoneal exudate macrophages leading to enhanced interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) production. In addition, CVT-E002 stimulated in-vivo immunoglobulin G (IgG) production in treated mice. These results identify some of the immunomodulating activities of CVT-E002 and suggest its use clinically for the modulation of immune responses.