1) Quercetin has a higher reduction potential compared with curcumin at three different pH settings and is comparable to Trolox at pH 7-9.5; 2) its TAC is 3.5 fold higher than curcumin; 3) it reduced LPS-induced ROS to near normal levels; 4) it reduced LPS-induced NO production. These data provide a physico-chemical basis for comparing antioxidants, with potential benefits individually or in combination.

graphene in 2004, diverse layered transition metal dichalcogenides with tunable band gaps have been shown to exhibit extraordinary electrical and optical properties in logic circuits, photodetectors, light-emitting diodes, gas sensors, and energy storage devices. [7][8][9][10][11][12][13][14] However, owing to their low mobility ceiling of a few hundred cm 2 V −1 s −1 , 2D-based fieldeffect transistors (FETs) still encounter a bottleneck for their application in highfrequency electronic devices. In this regard, indium selenide (InSe), with ultrahigh mobility near 1000 cm 2 V −1 s −1 at room temperature, has successfully attracted attention as one of the burgeoning III-VI group layered metal chalcogenides. The van der Waals layered Se-In-In-Se stacked structure, with a smooth surface and narrow band gap (1.26 eV), exhibits a perfect photoresponse to the visible spectrum. [15][16][17][18] Recent studies, which have focused on gating engineering with graphene, a passivation layer with hexagonal boron nitride or a self-assembled monolayer, and contact engineering with low work-function electrodes, have demonstrated that layered InSe possesses an intrinsically excellent charge transport and optoelectronic performance that are comparable with majority of 2D materials. [19][20][21][22][23][24][25] For instance, Wang Tunability and stability in the electrical properties of 2D semiconductors pave the way for their practical applications in logic devices. A robust layered indium selenide (InSe) field-effect transistor (FET) with superior controlled stability is demonstrated by depositing an indium (In) doping layer. The optimized InSe FETs deliver an unprecedented high electron mobility up to 3700 cm 2 V −1 s −1 at room temperature, which can be retained with 60% after 1 month. Further insight into the evolution of the position of the Fermi level and the microscopic device structure with different In thicknesses demonstrates an enhanced electron-doping behavior at the In/InSe interface. Furthermore, the contact resistance is also improved through the In insertion between InSe and Au electrodes, which coincides with the analysis of the low-frequency noise. The carrier fluctuation is attributed to the dominance of the phonon scattering events, which agrees with the observation of the temperature-dependent mobility. Finally, the flexible functionalities of the logic-circuit applications, for instance, inverter and not-and (NAND)/not-or (NOR) gates, are determined with these surface-doping InSe FETs, which establish a paradigm for 2D-based materials to overcome the bottleneck in the development of electronic devices. InSe TransistorsBecause of the down scaling limit of silicon-based devices, 2D materials with prominent mechanical flexibility and carrier transport performance have provided significant potential for their use in the new generation atomic electronic devices. [1][2][3][4][5][6] Following in the footsteps of the discovery of monolayer

No abstract

Tachyplesin is a small, cationic peptide that possesses antitumor properties. However, little is known about its action mechanism. We used phage display to identify a protein that interacted with tachyplesin and isolated a sequence corresponding to the collagen-like domain of C1q, a key component in the complement pathway. Their interaction was subsequently confirmed by both ELISA and affinity precipitation. Tachyplesin seemed to activate the classic complement cascade because it triggered several downstream events, including the cleavage and deposition of C4 and C3 and the formation of C5b-9. When TSU tumor cells were treated with tachyplesin in the presence of serum, activated C4b and C3b could be detected on tumor cells by flow cytometry, Western blotting, and confocal microscopy. However, this effect was blocked when the tumor cells were treated with hyaluronidase or a large excess of hyaluronan, indicating that hyaluronan or related glycosaminoglycans were involved in this process. Treatment of cells with tachyplesin and serum increased in membrane permeability as indicated by the ability of FITC-dextran to enter the cytoplasm. Finally, the combination of tachyplesin and human serum markedly inhibited the proliferation and caused death of TSU cells, and these effects were attenuated if the serum was heatinactivated or if hyaluronidase was added. Taken together, these observations suggest that tachyplesin binds to both hyaluronan on the cell surface and C1q in the serum and activates the classic complement cascade, which damages the integrity of the membranes of the tumor cells resulting in their death. (Cancer Res 2005; 65(11): 4614-22)