Objective: In this study we investigated the effect of Fluoxetine, a selective serotonin reuptake inhibitor, on the gravimetry, hematology and whole brain histopathology in the restrained stressed male albino rats. Methodology: Adult male Wistar albino rats weighing about 175-225 g were taken for the study and were divided into four groups of six animals each. Group I (control), Group II (stress induced), Group III (stress + withdrawal) and Group IV (stress + Fluoxetine, 20 mg/kg body weight, i.p.). The gravimetrical parameters, hematological parameters and whole brain histopathology of all the experimental rats were evaluated. Results: After 42 days of restraint stress, there was a significant (P ≤0.05) decrease final body weight, whole brain weight, Hb, RBC, MCV, MCH, total WBC and Platelets, whereas increase in Neutrophils, lymphocytes, eosinophils and monocytes in Group II of restraint stress rats when compared with their control group I. The stress withdrawal group (Group III) and drug Fluoxetine treatment (Group IV) shown significantly (P≤0.05) improvement in gravimetry, hematological parameters and whole brain histopathology in restraint stress compared to only stress induced group II. Conclusion: The drug Fluoxetine treatment could exert a protective effect on restrained stress induced alterations in gravimetrical parameters, hematological parameters and whole brain histopathology of male albino rats.
Background: Diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver. Liver damage is associated with the formation of oxygen derived free radicals. Reactive oxygen species as well as nitrogen species are responsible for nuclear DNA fragmentation and cell death. The aim of this study was to investigate the hepatoprotective effects of Nigella sativa seed. Materials and Methods: This work was conducted as part of Ph.D work under Department of Anatomy, Shri BM patil Medical College, BLDE University, Bijapur. University ethical committee and Institution Animal Ethical committee are approved the work according to CPCSEA (Govt of India) Rules. 18 rats were selected for this study and divided in to 3 groups each contains 6 rats, one group served as normal control, one group served as Streptozotocin (50mg/kg BW) induced diabetic control rats and one group served as diabetic rats treated with the nigella sativa seed powder(300mg/Kg body weight). Results: Histopathological observations of present study showed that nigella sativa treatment has proved its hepatoprotective effect in streptozotocin induced diabetic rats. The liver enzyme parameters significant change also supported histopathological findings. Conclusion: The results of present study concluding that Nigella sativa seed powder having hepatoprotective effect in streptozotocine induced diabetic rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.