Four-photon absorption (4PA) multimodal therapeutic agent
applied
to tumor ferroptosis process tracking is rarely reported. In this
paper, two functionalized terpyridine iron complexes (TD-FeCl
3
, TD-Fe-TD) with four-photon
absorption properties were designed and synthesized. The four-photon
absorption cross sections of TD-FeCl
3
reached 6.87 × 10–74cm8·s3·photon–3. Due to its strong near-infrared
absorption, TD-FeCl
3
has excellent
photoacoustic imaging (PAI) capability for accurate PA imaging. TD-FeCl
3
has an efficient longitudinal
electron relaxation rate (r
1 = 2.26 mM–1 s–1) and high spatial resolution,
which can be applied as T1-weighted magnetic resonance
imaging (MRI) contrast agent for tumor imaging in vivo. In addition, Fe3+ as a natural ferroptosis tracer, TD-FeCl
3
, is able to deplete glutathione
(GSH) effectively, which can further enhance the ferroptosis process.
We found that the series of cheap transition metal complexes has four-photon
absorption activity and can be used as multimodal (MRI/PAI) diagnostic
agents for tumor tracing processes.
The classic silver mirror reaction at room temperature in textbooks usually used glucose to react with silver nitrate and ammonium nitrate with the presence of caustic alkalis. But the aldehydes such as acetaldehyde and propionaldehyde were difficult to react under the same condition. In this paper, Na 2 CO 3 was used to mediate the reaction instead of caustic alkalis. In a newly formed ammoniacal-silver solution, a certain dose of Na 2 CO 3 solution and aldehydes (formaldehyde, propionaldehyde, n-butyraldehyde and glucose) were added in, and then a silver mirror formed within 2 min at room temperature without stirring or continuous shaking. This result broadened the knowledge of silver mirror reactions with aldehydes and made the scheme simple and easy, enabling the teaching to be more interesting. A survey result showed that 68.4% of preservice teachers at Anhui Normal University are willing to teach the experiment using this improved method.
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