Background:
Ulcerative colitis (UC) belongs to chronic colitis whose etiology and pathogenesis still have remained unclear. Hyperbaric oxygen therapy (HBOT) has been demonstrated to be effective for UC therapy. Still, evidence of its efficacy and safety is inconclusive. The purpose of the protocol is to evaluate the efficacy and safety of HBOT in UC therapy.
Methods:
This systematic review will retrieve studies that meet the requirements in Embase, MEDLINE, PubMed, Web of Science, Cochrane Library Central Register of Controlled Trials, the Chinese Biomedical Literature Database (CBM), China national knowledge infrastructure database (CNKI), Wei Pu database, Wan fang database, SinoMed, Google scholar, and Baidu Scholar from their inception to November 2020. Two authors are to be independent in their article selection, data collection, and research quality assessments. The primary outcome is the clinical effectiveness. And the secondary outcomes will include 4 criteria. RevMan 5.3 software will be utilized for analysis of the data.
Results:
The results of this study are to be submitted via a peer-reviewed journal.
Conclusions:
The study is to assess the effectiveness and safety of HBOT for UC and provide valid and reliable evidence regarding HBOT for UC.
INPLASY registration number:
INPLASY2020100118.
Abstract. The working process of the furrow opener is the state of movement between the working parts and the soil particles. The discrete element method (DEM) could not only truly express the geometrical characteristics of the soil particles but also be suitable for the experimental study on the furrow opener. In this paper, the physical and mechanical properties parameters of the surface soil particles were measured by the equipments, such as the soil triaxial apparatus, the direct shear apparatus, and so on. We established the discrete element 3-D model of the surface soil particles. The core ploughshare furrow opener was simulated by the discrete element software. We also revised the discrete element simulation model using the glass soil bin and the high-speed camera technology. The results of tests compared with discrete element simulation showed that both had the good correlation and the same laws. At the same time, we verified the validity of the simulation model parameter selection. We provided the effective method for the study and optimization design of the furrow opener.
Background
Decreased serum hemoglobin (Hb) level is associated with Immunoglobulin A nephropathy (IgAN) progression. However, whether serum Hb level is an independent prognostic factor of IgAN remains controversial. Herein, we aimed to investigate the prognostic value of serum Hb level in IgAN.
Methods
The Cochrane Library, Embase, PubMed and Open Grey databases were systematically searched and reviewed. Kidney disease progression of IgAN was defined as a doubling of serum creatinine (SCr), a 30% reduction in estimated glomerular filtration rate (eGFR), end-stage renal disease (ESRD), or death. We evaluated the hazard ratio (HR) between serum Hb level and the incidence of kidney disease progression in IgAN before and after adjusting for relevant covariates.
Results
We included nine studies with 10006 patients in the meta-analysis. As a continuous variable, we found that serum Hb was an independent prognostic factor of IgAN [unadjusted HR = 0.89, 95% confidence interval (CI) = 0.84–0.95,
I
2
= 98%; adjusted HR = 0.85, 95% CI = 0.79–0.91,
I
2
= 0%]. The sensitivity analysis confirmed the stability of these results. Consistently, as a dichotomous variable defined as the below/above cutoff for anemia, we observed a positive correlation between serum Hb and kidney disease progression in IgAN (unadjusted HR = 2.12, 95% CI = 1.44–3.12,
I
2
= 79%; adjusted HR = 1.65, 95% CI = 1.20–2.27,
I
2
= 0%).
Conclusion
Serum Hb level was independently correlated with the incidence of kidney disease progression in IgAN.
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