Efficacy and safety evaluation of hyperbaric oxygen therapy for patients with ulcerative colitis

Abstract

Background: Ulcerative colitis (UC) belongs to chronic colitis whose etiology and pathogenesis still have remained unclear. Hyperbaric oxygen therapy (HBOT) has been demonstrated to be effective for UC therapy. Still, evidence of its efficacy and safety is inconclusive. The purpose of the protocol is to evaluate the efficacy and safety of HBOT in UC therapy. Methods: This systematic review will retrieve studies that meet the requirements in Embase, MEDLINE, PubMed, Web of Science, Cochrane Library Central Register of Controlled Trials, the Chinese Biomedical Literature Database (CBM), China national knowledge infrastructure database (CNKI), Wei Pu database, Wan fang database, SinoMed, Google scholar, and Baidu Scholar from their inception to November 2020. Two authors are to be independent in their article selection, data collection, and research quality assessments. The primary outcome is the clinical effectiveness. And the secondary outcomes will include 4 criteria. RevMan 5.3 software will be utilized for analysis of the data. Results: The results of this study are to be submitted via a peer-reviewed journal. Conclusions: The study is to assess the effectiveness and safety of HBOT for UC and provide valid and reliable evidence regarding HBOT for UC. INPLASY registration number: INPLASY2020100118.

A General Overview on the Hyperbaric Oxygen Therapy: Applications, Mechanisms and Translational Opportunities

“…For instance, a phase 2A clinical trial demonstrated the possible benefits from HBOT in combination with steroids for patients with ulcerative colitis in terms of achieving higher rates of clinical remission, and a reduced probability of progression to second-line therapy during the hospitalization [ 61 ]. However, there are few studies in this field, and soon an updated meta-analysis and systematic review of the available evidence will be published [ 62 ]. Similar conclusions might be extrapolated to radiation-induced hemorrhagic cystitis and proctitis [ 63 ].…”

Systematic review with meta-analysis: effectiveness of hyperbaric oxygenation therapy for ulcerative colitis

“…Thirteen studies were finally included for statistical analysis. [13][14][15][16][17][18][19][20][21][22][23][24][25] Characteristics of the articles All included studies were RCTs. A total of 780 patients were included with 397 patients in the intervention group (Tables 1 and 2).…”

“…Although these Chinese studies did not describe the exact requirement of disease flares, some studies have provided detailed data about the disease severity of their enrolled patients. For example, Liang 13 included 15 patients (seven patients in the intervention group) with mild disease and 15 patients (eight patients in the intervention group) with moderate disease. Shen 14 included nine patients (three patients in the intervention group) with mild disease, 14 patients (four patients in the intervention group) with moderate disease, and two patients (one patient in the intervention group) with severe disease.…”

“…However, it was later proved to be related to the use of mesalamine. Liang 13 reported that some patients felt discomfort in their ears, which could be relieved by swallowing. No patient developed claustrophobia or psychological intolerance, vision changes, seizures, or other evidence of oxygen toxicity.…”