Papillary thyroid carcinoma (PTC) is considered the most prevalent thyroid malignancy. The association between Hashimoto’s thyroiditis (HT) and PTC is still unclear. We aimed to examine the clinicopathological impact of immunohistochemical staining of FOXP3 and Cytokeratin 19 in PTC and concomitant HT and their correlation with patients' outcome and survival. Eighty thyroid biopsies obtained from patients with PTC were immunostained by FOXP3 and CK19.The patients were treated by radioactive iodine (I131) and followed up. FOXP3 and CK19 expression were detected in 45% and 80% studied cases of PTC respectively. 16.7% of PTC with associated HT showed FOXP3+ lymphocytes in lymphocytic infiltrate of HT, while most of PTC associated HT express cytoplasmic CK19 positive Hurtle cells. FOXP3 was more expressed in PTC female patients more than 45 years with higher stage, lymph node, and distant metastasis, extracapsular extension, number of I131doses, and cumulative radioiodine doses with a highly statistically significant difference (p < 0.001). The relation was significant between CK19 immunostaining as regard 10-year Overall Survival and death (p value = 0.027 and 0.036, respectively). HT represents a step in the process of autoimmune inflammatory disease ending by the evolution of PTC with better prognosis, therefore appropriate follow up of these cases is needed. FOXP3 tends to be more expressed in PTC cases with worse prognostic variables and is predictable to become a recent prognostic and targeted therapy for PTC. There was a significant relation between CK19 immunostaining and 10 year overall survival.

Due to its rapidly spreading nature, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been announced as a pandemic by the World Health Organization in March 2020. 1 Although it is mainly a respiratory condition, it has other manifestations including anosmia and ageusia. 2 Skin manifestations are among the rare conditions associated with the COVID-19, these may include chilblain-like lesions, vascular lesions, varicella-like eruptions, and rash. 3 Here, we present a case of COVID-19 with multiple skin lesions associated with exacerbation of previous skin condition.

Striae Distensae (SD) are quite common complaint in dermatology practice. They are linear lesions of variable length and width according to the site and the causative condition. Several treatment modalities have been tried. To achieve satisfactory results, a combination therapy is often needed. To evaluate the efficacy and safety of fractional CO 2 laser versus carboxytherapy in the treatment of Striae Distensae clinically and radiologically. Thirty Egyptian patients with striae distensae, received a split body therapy: the left side was treated by fractional CO 2 laser and the right side was treated by carboxytherapy in the same session. Six sessions were done with 4 weeks apart. Clinical evaluation by measurement of the width of widest striae on both sides, global aesthetic improvement scale (GAIS), and Likert satisfaction scale. Radiological evaluation by measurement of cutaneous thickness of widest striae on both sides by ultrasonography. There was a highly statistically significant decrease in the median width of the widest striae distensae on both sides after the last session (P < 0.01). Regarding GAIS, satisfaction scale and ultrasound, there was highly statistically significant improvement on laser side than carboxytherapy side (P < 0.01) after last session. Both fractional CO 2 laser and carboxytherapy may be considered as safe and effective lines of treatment for striae distensae, but fractional CO 2 laser showed excellent improvement clinically, radiologically when compared with carboxytherapy which made it a promising module in treatment of striae distensae.

Sputnik V vaccine is adenovirus-based vaccine, it is a heterologous COVID-19 vaccine composed of two immunogenic components administered in two doses separated by at least 21 days. The first component includes a recombinant adenovirus type 26 (rAd26) vector, whereas the second includes a recombinant adenovirus type 5 (rAd5) vector. The full-length SARS-CoV-2 spike glycoprotein gene is included in both vectors (rAd26-S and rAd5-S). 2,3 We provide two examples of psoriasis development and aggravation after Sputnik V vaccination delivery. 3 The first case a 35-year-old woman with no history of any medication, no previous symptoms or signs for psoriasis or any systemic or cutaneous diseases or family history. A week after her first dose of Sputnik V vaccine, she suffered from single pruritic erythematous scaly plaque on her left leg, however, she sought medical advice and the family F I G U R E 1 A 35-year-old female with psoriatic lesions (A and B), histopathological picture (C), and dermoscopic picture (D)