Murraya koenigii L. Spreng, commonly known as curry leaves, is usually employed for their flavoring properties in the food due to its distinct aroma. It is a source of essential oil that has been studied extensively for its therapeutic potentials. The volatile constituents were obtained from leaves of M. koenigii by hydro-distillation method. It was then evaluated for its antibacterial potential on four different strains of bacteria, i.e., Micrococcus luteus, Bacillus subtilis, Escherichia coli, and Pasteurella multocida by agar well-diffusion method. The volatile constituents were then subjected to GC-MS analysis for their chemical composition. The volatile constituents showed the appreciable antibacterial spectrum against all four strains. The GC-MS analysis of volatile constituents revealed the presence of 4 unidentified and 7 identified major components. The unidentified and identified components constitutes 0.1932% and 99.1089%, respectively. The identified compounds were -pinene (3.4155%), -caryophyllene (15.8231%), sabinene (59.7176%), -pinene (10 .934 5%), -phella ndrene (5.25 56%), -terpinene (2.7974 %) a nd myrcene (1.8632%). The findings clearly suggest that the volatile chemical constituents obtained from M. koenigii has pronounced antibacterial activity against the strains used and the components responsible for it were scrutinized.

Diabetes mellitus (DM) is a global health problem with 422 million individuals around the world suffering from diabetes. Coriandrum sativum and Allium sativum possess numerous bioactive compounds which are of therapeutical significance. This study was undertaken to explore the combined potential of the two herbs in managing diabetes using diabetic albino mice as model. Extracts of both herbs were prepared and were orally administered in 10% Alloxan monohydrate (alloxan) induced diabetic albino mice over 28 days (in four doses with 7 day interval) to determine the optimal therapeutic and lethal doses. Safe dose limit of both extracts was deduced to be below 600 mg/kg (<600 mg/kg). Diabetic mice were given extracts (200 mg/kg and 400 mg/kg) over 56 days at 7 day intervals, and biological parameters were evaluated, at each interval, including Glucose level (mg/dl), HbA1C (%), Hepatic and Renal biomarkers, and Lipid profile. Garlic-coriander combination (at 400 mg/kg) was able to reduce glucose level (i.e.194.5 mg/dl) (P<0.05). Also, it showed a worthwhile effect on biological parameters as well as in Hepatic and renal tissues. Histological examination of hepatic and renal tissues indicated a restoration of normal tissue 26 architecture.