Evidence reported that cancers are spreading every nook and corner of the world at an alarming rate. Skin diseases like chronic skin inflammations, psoriasis and skin cancers have also been burning topic in today. Protections of a biological system are often hampered while skin gets damaged. Factors like UV, radiation, viruses, chronic diseases, genetic predispositions, food habits and environmental exposures might lead to skin cancers. In addition to these, urbanization and globalization may also contaminate the environment that may eventually modify several biological and genetic functions. USA, Europe and Australia are in the most dangerous zone to be exposed. We basically performed detailed search of PubMed, Google Scholar and Science Direct for literature search and collecting related information. On the other hand, experiments suggested that antioxidant components such as phenolic acid derivatives, flavonoids and flavonol found to be preventive against cancer cell proliferations. Moreover, antioxidants have been also evaluated as a protective agent against chronic inflammatory diseases as well. These molecules may participate as an additional therapy which could exert synergistic effects while applying with other chemotherapeutic agents. Our literature findings and hypothetical figure may establish a good correlation between skin cancer and antioxidant therapy. Therefore this study will be focused on skin cancer biology and some possible management strategies using antioxidant phyto-nutrients.
Diabetic polyneuropathy (DPN) is the most frequent, although neglected, complication of long-term diabetes. Nearly 30% of hospitalized and 20% of community-dwelling patients with diabetes suffer from DPN; the incidence rate is approximately 2% annually. To date, there has been no curable therapy for DPN. Under these circumstances, cell therapy may be a vital candidate for the treatment of DPN. The epidemiology, classification, and treatment options for DPN are disclosed in the current review. Cell-based therapies using bone marrow-derived cells, embryonic stem cells, pluripotent stem cells, endothelial progenitor cells, mesenchymal stem cells, or dental pulp stem cells are our primary concern, which may be a useful treatment option to ease or to stop the progression of DPN. The importance of cryotherapies for treating DPN has been observed in several studies. These findings may help for the future researchers to establish more focused, accurate, effective, alternative, and safe therapy to reduce DPN. Cell-based therapy might be a permanent solution in the treatment and management of diabetes-induced neuropathy.
The world is becoming uninhabitable owing to wide globalization. A large number of industries are contributing in water, soil, air, and environment pollution. Increased use of chemicals and accidental chemical spills are also hampering their surroundings. CFC containing tools and technologies are increasing due to higher demand in the market resulting ozone layers are highly affected which make the UV free towards the earth. Several environmental toxins and UV-radiation are the primary reasons for skin dysfunctions as a result skin loses its tone, strength, flux, density, and glamour that further lead to wrinkles and ageing. Chronic UV exposure may also lead to skin cancers. Pycnogenol, on the other hand, has been a major source for both flavonols and polyphenols, which is very potent against several diseases. Evidences suggest that pycnogenol prevents from multiple skin dysfunctions. Its components are equally potent against skin cancers as well. Moreover, several harmful downstream kinases and proteins are also inhibited by this component. In addition, it has been strongly proven beneficial in reducing ageing by preventing free radical generations, at the same time; it also helps in cell regeneration and replication. Thus, in this study we tried to identify the correlate possible molecular theories on ageing and related skin diseases. Finally, a possible benefit of pycnogenol using on skin disorders would be established.
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