Objective: Cocrystallisation is a promising method in order to increase the solubility and dissolution of poorly water-soluble drugs. The aim of this study was to prepare, formulate and evaluate glibenclamide (GCM) cocrystal in direct compress tablet dosage form using saccharin (SAC) as the coformer. Methods: GCM cocrystal with various stoichiometric ratios were prepared by the solvent drop grinding method. The co-crystal was characterized by a saturated solubility test and dissolution rate test, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-Ray Diffraction (PXRD). The tablet dosage form of GCM was formulated and evaluated compare with the conventional dosage form. Results: The solubility and dissolution rate of GCM-SAC cocrystals increased significantly compared with pure GCM, especially for 1:2 of ratio. The dissolution rate of cocrystal with ratio 1:2 increased by almost 91.9% compared with pure GCM. Based on the FTIR analysis, it showed the shifting of characteristic bands of GCM in the spectrum and there was no chemical reaction in GCM cocrystal. In PXRD measurement, the new crystalline peak was detected in the crystal habit of cocrystal compared with pure GCM and coformer. The new single melting of GCM-SAC cocrystal also was detected in DSC measurement. The tablets of GCM-SAC cocrystal were successfully prepared by direct compression method which rapidly disintegrated (1 min) and has higher dissolution compared with its pure form (32.36% greater than glibenclamide after 45 min). Conclusion: The tablet dosage form of GCM cocrystal with SAC as coformer was successfully prepared, formulated and improved its solubility and dissolution rate.
A reactor is a process device where a reaction takes place, be it a chemical or nuclear reaction and not physically. Nuclear reactors are used for various purposes, namely to create, regulate, and maintain a nuclear chain reaction at a constant rate. One method of monitoring corrosion is using an ultrasonic device to measure the thickness of the tank wall and an underwater camera tool to visually see the damage that has occurred and will provide a quantitative estimate of the corrosion rate that occurs in the system by comparing the initial weight and weight after a certain time. The corrosion rate value on the TRIGA 2000 reactor wall is obtained through the weight reduction method, and has an average corrosion value of 0.10 mmpy, while the type of corrosion that occurs on the TRIGA 2000 reactor wall is the type of intergranular corrosion. protective coating by coating organic compounds (lubricant) and controlling humidity and temperature.
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