This research is providing a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on pursuing the green chemistry principles. Therefore, a one-pot multicomponent cyclocondensation reaction through aldehyde interaction with ammonium acetate and 1,2-diketone was carried out in EtOH:H 2 O solvent under ultrasound irradiation. This protocol was utilized as an eco-effective synthetic route by applying CoFe 2 O 4 @SiO 2 @(-CH 2 ) 3 OWO 3 H nanocomposite as a nanocatalyst. The stabilized tungstic acid on 3-chloropropyl anchored to SiO 2 -coated CoFe 2 O 4 magnetic nanoparticles was designed, prepared, and applied as a recyclable heterogeneous acid catalyst to attain high product yields and short reaction times. The structure of nanocatalyst was confirmed by using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy dispersive spectroscopy (EDS), vibrating sample magnetometer (VSM), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) techniques, and the obtained organic derivatives were examined through melting point, FT-IR, and 1 H NMR analyses.

Pyrroles are widely spread worldwide because of their critical applications, especially pharmacology. An expedition method for one-pot synthesis of N-substituted pyrrole derivatives has been presented by a reaction between 2,5-dimethoxytetrahydrofuran and various primary aromatic amines in the presence of NiFe2O4 anchored to modified carbon hollow microspheres (NiFe2O4@MCHMs) as a recoverable reactive catalyst. The Classon-Kass method has been used to synthesize the pyrroles in excellent yields and short reaction times in the same direction with green chemistry rules. This reaction was carried out by employing NiFe2O4@MCHMs as a catalyst to make a simple procedure with short activation energy in water as an accessible, non-toxic, and biodegradable solvent. This catalyst provides a promising pathway to synthesize N-substituted pyrroles several times in a row through the recyclability without remarkable loss of its catalytic activity. The NiFe2O4@MCHMs nanocatalyst was characterized by applying FT-IR, XRD, FE-SEM, TEM, EDS, BET, TGA, VSM, and elemental mapping techniques. Also, the synthesized N-substituted pyrrole derivatives were identified using melting point, FT-IR, and 1H NMR analyses.

The aim of this study is offering a method for the synthesis of 2,4,5-trisubstituted imidazole derivatives based on pursuing the green chemistry principles. Therefore, one-pot multicomponent cyclocondensation reaction through aldehyde...