The impact of inflammatory markers such as systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI) on myelofibrosis (MF) prognosis was evaluated for the first time in this study. Data from 60 patients diagnosed with MF between March 2011 and September 2022 were retrospectively analyzed. In addition to disease-related markers, the impact of SII and SIRI on prognosis was evaluated. In our study, the overall median survival (OS) was 64 months. OS was significantly shorter in patients older than 65 years, with high ferritin and lymphocyte levels, transfusion dependence at diagnosis, platelet count below 100 × 109/L, Hb level below 8 g/dl, and high risk according to the dynamic international prognostic scoring system (DIPSS)-Plus score. When these variables were included in the multivariate Cox regression model, it was found that being older than 65 years, having a high ferritin value, being at high risk according to the DIPSS-plus score and Hb values below 8 increased the risk of death. Platelet-to-lymphocyte ratio (PLR) and SII index were lower in patients with a fatal outcome. No statistically significant relationship was found between SIRI and mortality. The findings of this study showed that low PLR and high ferritin were associated with poor prognosis in MF. Elevated SII and SIRI, evaluated for the first time in patients with myelofibrosis, did not predict prognosis. Since non-inflammatory variables play a role in the pathogenesis of MF, bone marrow indicators and systemic inflammation indicators derived from hematologic parameters may not be accurate.
Bir tesisin izlenmesi veya kontrolünde analog ya da dijital algılayıcılar ile toplanan verilerin kontrol elemanına taşınmasında, değerli ve yüksek işçilik maliyetleri içeren kablolar kullanılmaktadır. Uzun mesafelere veri taşınmasında ise sonradan oluşabilecek işçilik ve kablo maliyetleri de oluşabilir. Dolayısı ile endüstriyel otomasyon için kablosuz teknolojilerin kullanması birçok avantaj sağlayacaktır. Bu çalışmada kablosuz haberleşme ile su kuyularının otomasyonu yapılmıştır. Proje kapsamında iki kuyu ve bu kuyuların doldurduğu havuz dikkate alınmıştır. Su kuyularındaki su seviyeleri aşırı düşerse buna bağlı olan pompalar arızalanmakta ve bu yüzden birçok yerleşim yeri susuz kalmaktadır. Uzak mesafelerde kablolama maliyetini ve takibi kolaylaştırmak için her kuyuya ayrı otomasyon yapılmıştır. Pompaları korumak ve su sürekliliğini sağlamak için gerekli otomasyonun yapılmasında her bir kuyuda bir PLC ve buna bağlı wi-fi modüller vardır. PLC'ler gerekli otomasyonu sağlarken kuyular arası haberleşmede wi-fi modüller ile kablosuz olarak gerçekleştirilmektedir. Kuyulardan alınan sıvı seviye bilgileri karşılaştırılmış ve sıvı seviyesi yüksek olan kuyudan su çekilerek havuzu doldurulmuştur. Bütün bu düzeni takip edebilmek için bir Scada ekranı tasarlanmış ve bu sayede kuyulardaki su durumları, sistemin başlatılıp durdurulması ve arıza durumlarının takibi sağlanmıştır. Böylece uzak mesafelerde kablosuz veri iletimi ile arızaların önlenmesi ve su sürekliliğinin sağlanması için gerekli otomasyon sağlanmıştır.
This study aimed to find the depositional environment and formation conditions of the gypsumdominated Miocene succession alternated and intercalated with clastics and carbonates in the southwestern part of the Erzincan Basin. As a result of sedimentological, mineralogicalpetrographic investigations, it was determined that the gypsum in this sequence was formed as primary and secondary. Primary lithofacies; nodular anhydrite, selenitic, discoidal, gypsum arenitic secondary lithofacies; It is divided into massive, laminated, banded, nodular, brecciated, satin-spar. The facies repetitions and folds, fractures, cracks and faulting in the sequence showed the effect of tectonism with the water level fluctuations in the basin. In addition, these investigations revealed sedimentary structures such as cross-bedding, ripple undulations, chicken-wire, enterolithic and bacterial-algal structures, parallel laminations in gypsum lithofacies. In addition to these, it was understood that gypsum lithofacies were exposed to diagenetic processes under the influence of a hot-humid and semi-arid climate, organic matter activity, meteoric/underground-water and hydrothermal solution factors, and were subjected to high temperature, pressure, salinity and pH conditions.
In this study, learning environments and experiences used by Turkish learners (learners of Turkish) as a foreign language in listening, speaking, reading and writing processes were investigated. For this reason, out of class language learning environments and experiences used by 98 foreign students who completed their Turkish education in Eskişehir Osmangazi University Turkish Teaching, Application and Research Center (ESOGÜ TÖMER) were described with respect to the variable of geographical location. In this study, a case study format based on the qualitative research approach is used. A focus group interview is used to determine the language learning environments and experiences of the learners and the data were explained through descriptive analysis. Data from the result of the descriptive analysis show that out of class language learning environments and experiences of the learners do not differ according to the variable of geographical region; it is determined that out of class language learning environments and experiences activities vary according to individual differences. It is obtained that out of class activities change according to individual differences. To improve their language skills they used TV series, movies, music, and communicating with Turks. They prefer to use social media for their writing skills. Out of the lessons, not much was done by the learners in terms of reading.
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