Background. In order to reduce the mortality risk of aneurysm rupture, a timely diagnosis and treatment are vital. There are different reasons for aneurysm, such as hypertension, arteriosclerosis, and heredity. An efficient and cost-effective method to study the generation, development, and rupture of aneurysm and also analysis of treatment methods can accelerate progress. The Computational Fluid Dynamics is a well-known tool to simulate various phenomena. A reliable virtual modeling in biology depends on our knowledge about variety of characteristics, that is, biological features, structural properties, and flow conditions.Objective. Because of the vast research about the related subjects, an organized review is required. The aim of current review article is classification of the required foundations for a reliable virtual modeling of cerebral aneurysm, especially in the Circle of Willis.
Background and Aim: Cranfixer was approved in 2017 by the Food and Drug Administration of Iran as a skull flap fixation and also a burr hole cover. The effectiveness and safety of this commercial medical device were investigated in detail by the regulatory auditors.Methods and Materials/Patients: Cranfixer was used for ninety-five patients. Sixty patients were selected from a list if they had at least two follow-ups after surgery. The following variables were investigated: age, gender, number of Cranfixers, device loosening, infection, and prominence. In addition, a retrospective review was performed about the reason of surgery.Results: Flap loosening and infection were the major variables surveyed. On average, two Cranfixers were used for each patient. Patients' median age was 44 years. There was no sex preference (50% male). The craniotomy occurred in frontal (50%), occipital (3%), parietal (20%), and temporal (27%) lobes. Based on examination and CT imaging, no cases of loosening were observed. Just in one patient, one of two Cranfixers was infected (P<0.001).
Conclusion:The reliability and functionality of Cranfixer were proved in pre-market test and the results of this study confirm them. Cranfixer provides safe, reliable and long-term functionality.
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