Colorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different genes. Thus, in this study, we aimed to investigate whether Adenomatous Polyposis Coli gene (APC) mutation of rs41115in two locations such as 132.002 and 131.989 acts as a trigger or cause of colorectal cancer. Relatively, 30 blood samples of colorectal cancer patients and 30 normal blood samples as control group after colonoscopy and also confirmation of pathology report at Rohani Hospital in Babol (Iran) were investigated. The primers were designed in order to be included the rs41115 to identify the particular polymorphisms of gene. The polymerase chain reaction (PCR direct sequencing method) was used. Conclusively, deletion of adenine in two specific locations such as 131.989 and 132.002 has been identified, but there was no relationship between rs41115 polymorphisms located in adenomatous polyposis coli gene and colorectal cancer.
Introduction: Strongyloidiasis is a parasitic disease, which is more prevalent in tropical regions of the world. It is usually found in a chronic and limited disease form yet in some immunocompromised patients, it may become a life -threatening disease. Case Presentation: A 55 -year -old female, who was a known case for ulcerative colitis, referred to the hospital with nausea and vomiting. The patient was diagnosed with Strongyloidiasis due to Strongyloides stercoralis larvae, detected in the stool examination test and the biopsy specimens taken from the duodenum. The patient received subcutaneous ivermectin and reached a complete recovery. Conclusions: Strongyloides stercoralis often causes chronic and clinically asymptomatic infection; parasite number can increase substantially in the immunocompromised host, leading to hyperinfection, dissemination, and death if unrecognized. It is noteworthy to mention that screening for Strongyloides infection before the initiation of immunosuppressive therapy should be considered, particularly in endemic areas.
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