2020
DOI: 10.1016/j.jcol.2019.11.487 View full text |Buy / Rent full text
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Abstract: Colorectal cancer is one of the most important malignancies in the classification of gastrointestinal cancers. One of the predisposing factors at molecular level for this cancer is via WNT signaling which is associated with the vast numbers of different genes. Thus, in this study, we aimed to investigate whether Adenomatous Polyposis Coli gene (APC) mutation of rs41115in two locations such as 132.002 and 131.989 acts as a trigger or cause of colorectal cancer. Relatively, 30 blood samples of colorectal cancer … Show more

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“…The onset an development of CRC are induced by a combination of genetic and environmental factors, whose study is essential for the establishment of new prevention strategies. 5 Although most genes involved in CRC have been well characterized, the influence of additional environmental factors on this disease remains unclear. 4 When analyzing the patients' clinical profile, we observed a higher frequency of individuals aged !…”
Section: Discussionmentioning
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“…The onset an development of CRC are induced by a combination of genetic and environmental factors, whose study is essential for the establishment of new prevention strategies. 5 Although most genes involved in CRC have been well characterized, the influence of additional environmental factors on this disease remains unclear. 4 When analyzing the patients' clinical profile, we observed a higher frequency of individuals aged !…”
Section: Discussionmentioning
“…Factors such as age and family history, as well as genetic and environmental factors, have a positive correlation with CRC. [3][4][5] Most lesions follow a specific sequence of mutations, the "adenoma-carcinoma sequence": 4 initially, the normal epithelium is transformed into a hyperproliferative tissue; later, it loses organization and structure and acquires the capacity to form adenomatous polyps, which can evolve to CRC. 3 The microenvironment of the tumor has demonstrated an important regulatory role in CRC pathogenesis.…”
Section: Introductionmentioning
“…About 75% of both germline and somatic mutations are located on exon 15; this gene consists of more than 8,000 nucleotides and spans 21 exons 18 . However, APC gene somatic mutations may cause non-functional proteins, and even these small defects play an important role in colorectal cancer pathogenesis 19 . We aimed to investigate common somatic mutations in exon 15 of APC genes in colorectal cancer patients in East Azerbaijan, Iran.…”
Section: Discussionmentioning
“…It is well-recognized that the main product of the APC gene is involved mainly in the Wnt signaling pathway and has diverse functions in this pathway beyond regulation of Wnt components 18 . Also, APC gene mutation mainly affects proteins in the Wnt signaling pathway, and can lead to cell division excess in a few cancers, including colorectal cancer 19 . However, in CRC patients the APC mutation was reported as diverse variants 20 .…”
Section: Discussionmentioning
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