The child healthcare system in Ukraine is coordinated and managed at a central level by the Ministry of Health and at a local level by the regional health authorities. The Ministry of Health has executive the power for the implementation of state health policies and controls and manages state-owned health facilities. The system of public funding for the pediatric healthcare system is divided into two sources: central and local. Primary healthcare is organized by the National Health Service of Ukraine. Secondary level healthcare is mostly organized by the Ministry of Health, which gives money for hospitals and medical centers. Since 2014, due to reform and decentralization in Ukraine, local, regional, and city administrations received money from the Ukrainian government for the formation of decentralized budgets.
Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI. Materials and methods: The study included 75 children aged from 1 to 12 y diagnosed with ARI, who were treated with age-specific doses of antibiotics. The influence of children’s anamnesis, parents’ health on the development of AAD was studied with odds ratio calculation (OR). Results: In general, AAD incidence was 52%. The highest frequency 59.3% was observed in children under 3 y. AAD most often developed in children treated with amoxicillin – 92%. The greatest dependence of AAD development was connected with breastfeeding less than 6 months – OR was 7.65, preterm birth – 2.9, functional GIT disorders in anamnesis – up to 3.14, allergy – 2.33. The risk of AAD development increased with the age of parents more than 35 y – 5.03, at the age of parents less than 18 and older than 35 y – 4.09, parents’ allergies - 3.74 and parents smoking - 2.43. Conclusions: The most important factors of AAD development on antibiotics therapy in children with ARI are breastfeeding less than 6 months, functional GIT disorders and allergic conditions in anamnesis. Suboptimal age and parents’ health (GIT disorders, allergic conditions and unhealthy habits) also increase the risk of AAD development.
The purpose of this study was to determine serum zinc, iron, magnesium, copper, potassium, calcium, and sodium levels in acute rotavirus infection and convalescence period in children. Materials and methods. We examined 86 patients aged from 4 months to 5 years with clinical and laboratory signs of rotavirus infection. The I group-43 children with RVI in acute period. The II group-43 children with RVI in convalescence period. The control group included 14 healthy children at the same age. The content of macro-and microelements (zinc, iron, magnesium, copper, potassium, calcium and sodium) in blood serum was determined by atomic absorption spectrophotometry. Feces samples were used for Cito Test Rota (Pharmasco). Cito test was used for rotavirus antigen detection in feces. Statistical analysis was performed by Excel. Student's t-test was used to evaluate differences between study groups. Results. The acute period of the disease in children with rotavirus infection was characterized by a significant increase of copper in blood serum compared with the control group. At the same time, a significant decrease of iron, magnesium, zinc, potassium, calcium, sodium were determined in patients with rotavirus infection, compared with apparently healthy children. After standard treatment only the indicators of magnesium, potassium and sodium reached the same indices of control group children. Conclusions. The detected changes in the mineral status of patients with rotavirus infection suggest the need for treatment correction. Correction of micro-and macroelements imbalances in patients with rotavirus infection possibly should be aimed at the metallo-drugs inclusion in complex treatment as well as medicines which improve absorption of the latter in the intestine.
The aim of the study was to evaluate the condition of the cardiovascular system and the effect of the combined preparation of magnesium and vitamin B6 in children with secondary cardiomyopathy on the background of chronic tonsillitis. Materials and methods: 100 children at the aged of 13–17 years were surveyed, including 60 patients with secondary cardiomyopathy with chronic tonsillitis. And the group I consisted of 45 children receiving standard treatment, group II – 15 patients who, along with standard treatment, received the drug magnesium. The control group consisted of 40 healthy children. To assess the condition of the cardiovascular system and vegetative regulation, we performed electrocardiographic examination (ECG), exercise test and ECG control, cardiointervalography with clinoortostatic test. The concentration of magnesium in the serum was determined by atomic absorption spectrophotometry. Also, we have provided the requirements of the principles of bioethics and drafted a protocol in accordance with the basic principles of the Helsinki Declaration. Results: In addition to the standard treatment of children with magnesium drug, there was a significant decrease in the frequency of sinus arrhythmias, disorders of the intraventricular conduction, and the processes of repolarization, extrasystole, sinus suchchardia were not observed in any of the patients. The normalization of magnesium in the serum of patients was observed. Conclusions: Supplementation of combination therapy with magnesium and B6 helped to improve myocardial electrophysiology and cardiac output, as well as to normalize the serum magnesium in children with secondary cardiomyopathy.
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