Purpose:
Ganoderma lucidum, a kind of mushroom used for its
antioxidant, anti-inflammatory, and immunomodulatory activities, was
investigated in the present study for its possible healing effect on
calvarial defects with bone grafts.Methods:Wistar male rats (n = 30) were divided into 3 groups: 1) the
control (defect) group (n = 10), 2) defect and graft group
(n = 10), and 3) defect, graft, and G.
lucidum treated group (n = 10). The G.
lucidum was administered to the rats at 20 mL/kg per day via
gastric lavage.Results:In the defect and graft group, osteonectin positive expression was observed
in osteoblast and osteocyte cells at the periphery of the small bone
trabeculae within the graft area. In the defect, graft, and G.
lucidum treated group, osteonectin expression was positive in
the osteoblast and osteocyte cells and positive osteonectin expression in
new bone trabeculae. The expression of matrix metalloproteinase-9 (MMP-9)
was positive in the inflammatory cells, fibroblast cells, and degenerated
collagen fibril areas within the defect area.Conclusion:This study shows that, with its antioxidant and anti-inflammatory properties,
G. Lucidum is an important factor in the treatment of
calvarial bone defects.
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