Étude du rôle de l'homocystéine et d'autres marqueurs de l'intoxication endogène dans la pathogenèse du développement du lichen planIntroduction. Le lichen plan (LP) est une dermatose poly-étiologique chronique selon son mécanisme d'apparition qui se manifeste par une éruption papuleuse sur la peau et les muqueuses, ainsi que par des démangeaisons intenses. L'objectif de cette étude est d'identifier et d'analyser le niveau de marqueurs d'intoxication endogène dans le plasma sanguin de patients atteints de lichen plan selon la gravité et la durée de la maladie. Matériaux et méthodes. Nous avons surveillé 48 patients atteints de LP: 20 hommes et 28 femmes. Chez 31 patients, la dermatose a duré moins de 2 ans, chez 17 patients -plus de 2 ans. Un faible degré de LP a été diagnostiqué chez 17 patients, un moyen -chez 31. On a déterminé dans le sang de tous les patients les taux de l'homocystéine (Hcy), des carbonyles des protéines modifiées par oxydation (C-PMO) et des peptides d'un poids moléculaire moyen (PPMM). ABSTRACTIntroduction. Lichen planus (LP) is a chronic poly-etiologic dermatosis by the mechanism of its development, manifested by papular rash on the skin and mucous membranes, severe itching. The objective of the study was to determine and analyze the levels of endogenous intoxication markers in blood plasma of the patients with lichen planus depending on severity and duration of the disease. Materials and methods. 48 patients, 20 men and 28 women, participated in the study. 31 patients had suffered from dermatosis for about 2 years, and 17 patients for over 2 years. Mild LP was diagnosed in 17 patients and moderate LP in 31 patients. The blood levels of homocysteine (HC), carbonyl groups of oxidative modified proteins (CG-OMP) and medium molecular weight peptides (MMWP) were determined in all the patients. Results. Significantly increased blood plasma levels of HC, MMWP and CG were found in patients with lichen planus as compared to the control group. The patients with severe and prolonged course of dermatosis had more evident disturbances in the content
your fear. If it is more than six, you need to work on your condition, because it is already capable of harming your health. Conclusion.The proposed technique is simple to implement and quite effective. In addition, there are several quite effective psycho-hygienic methods of dealing with excessive anxiety. But it's necessary keep in mind that any psychological technique is not a magic pill of instant action. All these exercises will be effective only if to repeat them regularly.
Objective — to investigate the variability of vascular endothelial growth factor (VEGF) in localized scleroderma (LS), characteristics of the disease in different age groups. Materials and methods. The study included the clinical evaluation of 78 patients (27 men, 51 women) with localized scleroderma aged (43.2 ± 7.28) years. All patients underwent clinical, laboratory, and enzyme immunoassay investigation of VEGF. The criteria for inclusion in the study were: the presence of localized scleroderma and the absence of signs of a systemic process. Results and discussion. It has been proven that localized scleroderma is genderrelated, more often recorded in women (65.4 %, p < 0.05), with an attributive risk of 50.0 % compared to men. Late diagnosis of the disease was proven in 78.2 % of patients. The age and gender characteristics of this pathology were determined — men are more likely to get sick at a young age (up to 20 years; 22.2 % of the surveyed), however, women over the age of 55 prevail (p < 0.05). Women sought dermatological help earlier compared to men (29.4 %; p < 0.05), but had a higher risk of early progression (p < 0.05). Among the clinical forms of localized scleroderma, most of the cases (70.5 %) were of the plaque form. In 15.4% of cases, a linear form was diagnosed, in 9.0% lichen sclerosus, in 5.1 % — Pasini—Pierini idiopathic atrophoderma. The plaque form of LS was significantly more often detected in women (80.3 %), and the linear form and lichen sclerosus — in men (22.2 % each). The average number of lesions was 2.8 ± 1.12. Three lesions were found in almost half (43.6 %) of the patients, one lesion – in 23.1%, two lesions – in 16.7%, four lesions – in 11.5%. Five or more lesions were present in 4 (5.1 %) patients. It has been found that the highest content of VEGF was observed in classic plaque form (p < 0.05), the lowest — in Pasini—Pierini idiopathic atrophoderma (p < 0.05). Ushaped age dependence of the disease was determined: high content of VEGFA in patients under the age of 20 (p < 0.05), with a significant decrease of VEGFA in patients aged 20—35 years (p < 0.05) and further increase in those aged 35 to 55 years (p < 0.05). It was established that VEGFA level increased at patients with early progression of the disease — in the first 2 years after the start of clinical manifestations against the group of patients with slow progression — more than 6 years (p < 0.05). In assessment of gender dependence, we found a higher content of VEGFA in female patients compared to male patients (p < 0.05). Conclusions. Localized scleroderma has gender and agerelated characteristics and is 50.0 % more often recorded in women. Among men, young patients predominate. Studying the pathogenesis of LS and assessing the proliferative function of the endothelium of the disease will make it possible to predict the course of the disease, improve the diagnosis and treatment.
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