The preparation of biocompatible normal (oil‐in‐water, o/w) microemulsions (ME) with different oil phases (peppermint oil, trans‐anethole, vitamin E, jojoba oil) and stabilized with d‐α polyethylene glycol succinate (TPGS‐1000) and isobutanol (iso‐BuOH) is presented. Results of average particle diameter determination, Dp, indicated 6.35 ≤ Dp ≤ 10.24 nm. These ME showed excellent colloidal stability (−40 and +40 °C) and, without any drug loaded, decreased dramatically the viability of leukemia cells (K562), 60–90 %, in 24 hours. Besides, this behavior was potentiated when paclitaxel (PTX, an anticancer drug) was loaded in the transanethole microemulsion, where the cell viability decreased until 2 % at 0.5 μg/mL of PTX. These MEs are precursors to synthetize polymeric nanocapsules when coated with a thermo or pH – sensible polymer with potential for cancer treatment.
Pin-on-disk tests were performed to evaluate the wear behaviour of a 2024 aluminium alloy metal matrix composite (MMC) reinforced with 52 vol.% of TiC particles (Al-2024/TiC) in a fabricated and thermal-treated (T6) condition. The MMC was produced via pressureless infiltration of partially sintered TiC preforms with an average particle size of 1.1 μm at 1200 °C for 2 h under flowing argon. Microstructural and mechanical characterisation were carried out on both the monolithic alloy (MM) and the MMC with and without heat treatment. The effect of T6 heat treatment on the tribological behaviour of MMC has been investigated under dry sliding wear conditions under normal loads of 2, 5 and 10 N against ceramic α-Al2O3 and SAE 52100 steel spherical counterparts. Results indicate a substantial improvement in the microhardness (289–343 HV), hardness (25–34 HRC), and wear resistance of the MMC after T6 heat treatment (1 × 10−3 to 5 × 10−5 mm3/Nm). For a better understanding of the wear mechanisms, surfaces of the worn tracks were studied. Oxidation and abrasion were found as the dominant wear mechanisms in both MM and MMC samples. Even though MM exhibited a lower coefficient of friction (COF) (0.50–0.80), composites showed superior wear resistance by 5-fold higher than the base alloy.
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