Preparation of Peppermint Oil-Based Nanodevices Loaded with Paclitaxel: Cytotoxic and Apoptosis Studies in HeLa Cells

Flores-Villaseñor, Sergio E.; Peralta, René D.; Padilla‐Vaca, Felipe; Meléndez‐Ortiz, H. Iván; Ramirez-Contreras, Jorge Carlos; Franco, Bernardo

doi:10.1208/s12249-019-1399-7

Cited by 7 publications

(4 citation statements)

References 43 publications

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“…Various EOs incorporated with chemotherapeutic agents showed an enhancement in cytotoxicity in cervical cancer cells. Nanoemulsions of cinnamon, peppermint, clove, lemon, salvia, chamomile, frankincense, garlic, and ginger oils loaded with chemotherapeutic agents (e.g., bleomycin, paclitaxel, ifosfamide, mitomycin C, and doxorubicin) presented a major pro-apoptotic capability in HeLa cells compared with the chemotherapeutic agents alone (Table 5) [141][142][143][144][145][146]. Furthermore, peppermint-oil-based microemulsion loaded with paclitaxel was shown to be stable under centrifugal and freeze-thaw stress, and ≈90% of paclitaxel was released in the first 48 h [142].…”

Section: Combining Essential Oils With Conventional Treatmentsmentioning

confidence: 99%

“…Nanoemulsions of cinnamon, peppermint, clove, lemon, salvia, chamomile, frankincense, garlic, and ginger oils loaded with chemotherapeutic agents (e.g., bleomycin, paclitaxel, ifosfamide, mitomycin C, and doxorubicin) presented a major pro-apoptotic capability in HeLa cells compared with the chemotherapeutic agents alone (Table 5) [141][142][143][144][145][146]. Furthermore, peppermint-oil-based microemulsion loaded with paclitaxel was shown to be stable under centrifugal and freeze-thaw stress, and ≈90% of paclitaxel was released in the first 48 h [142]. The combined therapy of monoterpenoid carvacrol-fabricated chitosan NP and doxorubicin, a topoisomerase inhibitor, has also been reported to have greater anticancer effects on HeLa cells with an IC 50 of 5.66 µg/mL, compared to doxorubicin treatment alone (IC 50 6.30 µg/mL) [147].…”

Section: Combining Essential Oils With Conventional Treatmentsmentioning

confidence: 99%

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Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Abd Rashid,

Mohamad Najib,

Abdul Jalil

et al. 2023

Antioxidants

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Cervical cancer is a prevalent and often devastating disease affecting women worldwide. Traditional treatment modalities such as surgery, chemotherapy, and radiation therapy have significantly improved survival rates, but they are often accompanied by side effects and challenges that can impact a patient’s quality of life. In recent years, the integration of essential oils into the management of cervical cancer has gained attention. This review provides an in-depth exploration of the role of various essential oils in cervical cancer, offering insights into their potential benefits and the existing body of research. The review also delves into future directions and challenges in this emerging field, emphasizing promising research areas and advanced delivery systems. The encapsulation of essential oils with solid lipid nanoparticles, nanoemulsification of essential oils, or the combination of essential oils with conventional treatments showed promising results by increasing the anticancer properties of essential oils. As the use of essential oils in cervical cancer treatment or management evolves, this review aims to provide a comprehensive perspective, balancing the potential of these natural remedies with the challenges and considerations that need to be addressed.

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Section: Combining Essential Oils With Conventional Treatmentsmentioning

confidence: 99%

Section: Combining Essential Oils With Conventional Treatmentsmentioning

confidence: 99%

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Abd Rashid,

Mohamad Najib,

Abdul Jalil

et al. 2023

Antioxidants

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“…Likewise, Zeta potential (ZP) is a measure of effective electric charge present on the surface of the nanoformulation and quantifies the charge stability and degree of electrostatic repulsion between the particles in the colloidal solution. The average PSA and poly dispersity index (PDI) of LO-NE gives information about the size of the particle and their homogeneity was analyzed on a Photon Correlation Spectroscopy (Malvern Zetasizer 3000 HS) by diluting the test samples in ratio of 1:50 with water [23].…”

Section: Particle Size Poly Dispersity Index and Zeta Potential Analysismentioning

confidence: 99%

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

Kaur¹,

Pancham²,

Kaur³

et al. 2020

JBNB

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Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (S mix ). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 -104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC 50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi's model How to cite this paper:

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“…The most famous example could be Taxol (Figure 3) which is widely used to treat many types of cancers, such as breast cancer [61,62,63], ovarian cancer [64,65,66], lung cancer [67,68,69], cervical cancer [70,71,72], etc. Taxol and its semi-synthetic derivative cabazitaxel furthered interest in the study of oxetanes.…”

Section: Oxetanesmentioning

confidence: 99%

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

Harmalkar

Choi

et al. 2019

Molecules

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Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3–7 membered rings.

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Preparation of Peppermint Oil-Based Nanodevices Loaded with Paclitaxel: Cytotoxic and Apoptosis Studies in HeLa Cells

Cited by 7 publications

References 43 publications

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

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Preparation of Peppermint Oil-Based Nanodevices Loaded with Paclitaxel: Cytotoxic and Apoptosis Studies in HeLa Cells

Cited by 7 publications

References 43 publications

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Essential Oils in Cervical Cancer: Narrative Review on Current Insights and Future Prospects

Synthesis and Characterization of &lt;i&gt;Citrus limonum&lt;/i&gt; Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

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Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application