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In glaucomatous patients, preservative-free 0.1 timolol treatment improved their QoL. Similar dry eye signs or symptoms improved after 3 months of treatment reducing dryness, hyperemia, follicular hyperplasia, and foreign body sensation.

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No significant difference in CCT was found between patients treated with PGA and TCAI, suggesting that these topical medications did not statistically and clinically change the CCT.

Purpose To evaluate whether a difference in central corneal thickness (CCT) between the paired eyes could be associated to worse glaucoma in the thinner cornea eye. Methods From 16 different glaucoma centres, at least 50 glaucomatous patients were saved on the Italian Glaucoma Register. Eight hundred and sixteen glaucomatous patients were found in the register. CCT, ophthalmoscopic cup/disc ratio, mean deviation (MD), pattern SD (PSD), and intraocular pressure (IOP). The difference (D) between the paired eyes was calculated for all the considered parameters and two subgroups were created on the basis of DCCT. Because the difference between the two eyes could be positive or negative, the absolute value of D was considered for all the measurements. Three different DCCT cutoffs were selected: 10, 15, and 20 mm. Student's t-test was used to compare the subgroups. Results When the entire group was divided in two subgroups using 20 mm as DCCT cutoff, no significant difference was found for DIOP ( À 0.38 ± 2.53 (mean ± SD) mm Hg and À 0.07 ± 2.35 mm Hg, respectively) between the two subgroups. Significant (Po0.001) difference was found for DMD (6.58 ± 7.30 and 3.14 ± 4.22 dB, respectively), DPSD (3.92 ± 4.01 and 2.16±2.57, respectively), and DC/D (0.11±0.14 and 0.08±0.11, respectively) between the two subgroups. No significant correlation was found between DCCT and the other parameters. Conclusion The DCCT between the two eyes could be associated to a worse glaucoma in the thinner cornea eye. Keywords: glaucoma; central corneal thickness; visual field damage; difference between eyes IntroductionAs glaucoma is a chronic asymmetric progressive degenerative disease of the optic nerve head, most patients with glaucoma can have a different stage of the disease between the two eyes.Although central corneal thickness (CCT) measurements are usually highly symmetric between paired eyes, approximately 6-7% of individuals do manifest significant interocular CCT asymmetry. 1-3 CCT has been identified as a substantial glaucoma risk factor, 4-8 and glaucomatous damage often presents in an asymmetric fashion. 9,10 The percentage of normal-tension and hightension glaucoma patients with unilateral VF loss has been estimated to be approximately 25-35%. 9 Asymmetric CCT was already associated with asymmetric primary open-angle glaucoma (POAG) in a retrospective study. 11 In a later study by the same group, however, asymmetric POAG was associated with asymmetric dynamic contour tonometry but not Goldmann applanation tonometry or CCT. 12 The aim of the study was to evaluate whether a difference in CCT between paired eyes could be associated to worse glaucoma in the thinner cornea eye. Patients and methodsThis is a retrospective, cross-sectional study. Institutional review boards and ethics committees at the institutions gave their approval of this study. This study followed the principles of the Declaration of Helsinki.From 16 different glaucoma centres, at least 50 glaucomatous patients for each centre were saved on the Italian G...