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Epilepsy is a chronic disorder characterized by a spontaneous tendency to recurrent seizures which affects patients' cognitive, behavioral, psychological, and social functioning. Epileptic patients face various problems that result in a lower quality of life. Seizure frequency, drug side effects, psychological comorbidity, and stigma are the major factors affecting the quality of lives of patients with epilepsy. Depression, anxiety, psychosis, and cognitive impairment are some of the comorbid psychiatric problems accompanying the clinical picture in epilepsy. Also the role of antiepileptic drugs (AEDs) in psychopathology of epilepsy should not be underestimated. One of the most important reasons why health-related quality of life (HRQOL) has become important for epileptic patients is related with well-known characteristics of this disorder. Its chronic nature, presence of unexpected, intractable and frequent seizures, and stigma are some of these characteristics among others. With the review of the current literature, it can be concluded that there is still a need for further scientific research to find out more clear relation between epilepsy, comorbidities, and HRQOL.

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ÖzetYemek yeme epilepsisi refleks epilepsinin nadir bir tipidir. Yemeyle tetiklenen nöbetler genellikle lokalizasyon ilişkilidir ve sıklıkla kompleks parsiyel tiptedir. Daha az sıklıkta, bu nöbetler sekonder jeneralize olan ya da olmayan basit parsiyel tiptedir. Bu yazıda, frontal menengioma ameliyatı sonrası gelişen, yemek yeme epilepsisi olan 38 yaşında kadın hasta sunuldu. Hasta, üç yıldır hiçbir antiepileptik tedaviye yanıt vermeyen sekonder jeneralize nöbetlerden yakınıyordu. Refleks ve refleks olmayan nöbetleri mevcuttu. Ancak çoğu nöbeti yemek yeme veya su içme ile tetikleniyordu. Bu olgu yemek yeme epilepsisinin sekonder jeneralize tonik klonik nöbetlerle giden nadir görülen bir formudur.Anahtar sözcükler: Yemek yeme epilepsisi; frontal meningioma rezeksiyonu; jeneralize tonik klonik nöbetler. SummaryEating epilepsy (EE) is a rare type of reflex epilepsy. Eating-induced seizures are, in general, localization-related, and most commonly of the complex partial type. Less frequently, these seizures are of the simple partial type with or without secondary generalization. Here, we report a case of a 38-year-old female patient with EE after frontal meningioma resection. She had suffered from secondary generalized seizures unresponsive to any antiepileptic therapy for 3 years. She had both reflex and non-reflex seizures. However, most of the seizures were triggered by food or water deglutition. This was an unusual case of EE with secondary generalized tonic-clonic seizures.

This study aimed to compare neuronal function in the lower limbs of elite footballers and an age-matched control group. Conduction velocity, response latency and amplitude following electrical stimulation were investigated. Thirty male football players and 30 untrained males comprised the subject and control groups, respectively. We showed that professional football players have significantly slower sural nerve conduction velocity than untrained controls (p<0.05). Although we found no signs of neuropathy, mild changes in nerve conduction velocity were evident in the sural nerve of the players. Motor conduction velocity of tibial nerve was also significantly prolonged in this group when comparing dominant and non-dominant extremities (p<0.05). The tibial nerve muscle action potential amplitude was lower in the players’ dominant limbs compared with the controls (p<0.05). We found no statistical difference in motor conduction velocities, distal latencies and amplitudes of the common peroneal nerve when comparing players and controls in both dominant and non-dominant limbs (p>0.05). Our results showed abnormalities of function in the sural and tibial nerves in football players compared with untrained controls, which may indicate early signs of neuropathy.

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HINT1 gene mutations cause an axonal neuropathy with some specific findings including presence of neuromyotonia, autosomal recessive inheritance, onset in the first decade, and primary motor involvement. We described an 18-year-old female patient who presented to the clinic with gait instability and muscle stiffness. A homozygous novel c.180_181delAT (p.Ser61Profs*8) variant in the HINT1 gene was found by clinical exome analysis. Parents were heterozygous for the same variant. The patient was diagnosed with autosomal recessive axonal neuropathy with neuromyotonia. The presence of neuromyotonia must be evaluated in patients with hereditary axonal neuropathies as this can help the diagnosis prior to genetic testing.