Positive impact of levetiracetam on emotional learning and memory in naive mice

Çelikyurt, İpek Komşuoğlu; Ulak, Güner; Mutlu, Oğuz; Akar, Füruzan; Mülayim, Serap; Erden, Faruk; Komşuoğlu, Sezer

doi:10.1016/j.lfs.2011.11.003

Cited by 20 publications

(9 citation statements)

References 30 publications

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“…In our previous studies, we have shown the positive impact of levetiracetam on emotional learning and memory in naive mice (Celikyurt et al, 2012). We have previously reported that gabapentin, a GABA analogue, enhances cognitive performance in naive mice (Celikyurt et al, 2011a).…”

Section: Discussionmentioning

confidence: 92%

Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

et al. 2012

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Section: Discussionmentioning

confidence: 92%

Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

et al. 2012

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“…Newer AEDs, namely levetiracetam, gabapentin and lamotrigine on the other hand, are apparently safe with respect to the cognitive function [23]. Levetiracetam, apparently enhances memories in the animal models [24] and enhances quality of life in brain tumour patients having epilepsy [25]. Of late, verbal memory improvement in highgrade glioma patients on levetiracetam has been demonstrated [26].…”

Section: Discussionmentioning

confidence: 99%

Epileptic seizures in patients with glioma: A single centrebased study in China

Huang¹,

Cao²,

Wang³

2017

Trop. J. Pharm Res

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“…Some studies have demonstrated spatial memory enhancing effect of lamotrigine22, and topiramate23, and fear learning enhancement with levetiracetam24, while others have shown decreased learning performance with levetiracetam25, valproate26, and topiramate21. No effect on learning and memory has been demonstrated with treatment of valproate25, levetiracetam2426, and lamotrigine23. It is difficult to pinpoint which of the numerous differences between the drugs may account for the divergent behavioural outcomes after long term exposure.…”

Section: Discussionmentioning

confidence: 99%

Effect of lamotrigine, levetiracetam & topiramate on neurobehavioural parameters & oxidative stress in comparison with valproate in rats

et al. 2016

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Background & objectives:Though newer antiepileptic drugs are considered safer than conventional antiepileptics, the effects of lamotrigine, levetiracetam and topiramate on neurobehavioural functions are yet to be established. This study evaluated neurobehavioural parameters and oxidative stress markers in brain tissue of rats treated with lamotrigine, levetiracetam and topiramate compared to sodium valproate.Methods:Five groups of male Wistar rats were treated respectively with normal saline (control), sodium valproate (370 mg/kg), lamotrigine (50 mg/kg), levetiracetam (310 mg/kg) and topiramate (100 mg/kg) for 45 days. Neurobehavioural parameters were assessed using elevated plus maze (EPM), actophotometer, rotarod, passive avoidance and Morris water maze (MWM) at baseline and at the end of treatment. Oxidative stress parameters [malondialdehyde (MDA), reduced glutathione (GSH) and superoxide dismutase (SOD)] were estimated in rat brain at the end of treatment.Results:Valproate and lamotrigine showed no significant effect on learning and memory in passive avoidance and MWM tests. However, levetiracetam and topiramate reduced retention memory significantly as compared to control (P<0.01) and lamotrigine (P<0.05) groups. Performances on EPM, rotarod and actophotometer were not significantly different between the groups. In comparison to control group, MDA was higher in the levetiracetam and topiramate (360.9 and 345.9 nmol/g of homogenized brain tissue, respectively) groups. GSH and SOD activity were significantly reduced by valproate and levetiracetam treatment. Lamotrigine did not induce significant oxidative stress.Interpretation & conclusions:Long-term and therapeutic dose treatment with levetiracetam and topiramate significantly impaired learning and memory, which was not seen with valproate and lamotrigine in rats. Levetiracetam, topiramate and valproate augmented oxidative stress, whereas lamotrigine has little effect on it. These antiepileptic drugs are used in clinical practice, hence pharmacovigilance studies are required to evaluate their safety profile.

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Positive impact of levetiracetam on emotional learning and memory in naive mice

Cited by 20 publications

References 30 publications

Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

Epileptic seizures in patients with glioma: A single centrebased study in China

Effect of lamotrigine, levetiracetam & topiramate on neurobehavioural parameters & oxidative stress in comparison with valproate in rats

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