Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

Çelikyurt, İpek Komşuoğlu; Ulak, Güner; Mutlu, Oğuz; Akar, Füruzan; Erden, Faruk; Komşuoğlu, Sezer

doi:10.1016/j.lfs.2012.09.020

Cited by 4 publications

(4 citation statements)

References 30 publications

(25 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few studies have examined the effect of lamotrigine on cognition, but in mice at 40mg/kg i.p. it prolonged the time in the learned quadrant in a Morris Water Maze probe trial of retention and improved latency in a passive avoidance test (Celikyurt et al, 2012). In contrast, lamotrigine did not cause any significant change in working memory performance (Shannon and Love, 2004) or attention in a five-choice serial reaction time task in rats (Shannon and Love, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…All treatments were administered by intraperitoneal injection (2ml/kg) 60min before each behavioral test. Doses of lamotrigine were selected from previous rat cognitive behavioral studies (Brody et al, 2003b; Celikyurt et al, 2012). …”

Section: Methodsmentioning

confidence: 99%

“…Although not approved to treat schizophrenia, clinical studies have noted lamotrigine may improve some symptoms in a clozapine-resistant patient population (Goff, 2009; Tiihonen et al, 2009). Notably, lamotrigine and related voltage-gated sodium channel blockers attenuate cognitive deficits in methamphetamine- and PCP-treated rats and transgenic mice models used to investigate schizophrenia, including visual and spatial learning (Celikyurt et al, 2012), reversal learning (Large et al, 2011), and PPI deficits (Brody et al, 2003b; Nakato et al, 2010). The mechanisms underlying these pro-cognitive effects are unclear but could involve modulation of cortical glutamate release.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

Gaskin

Toledo-Rodriguez

Alexander

et al. 2016

IJNPPY

View full text Add to dashboard Cite

Background:Dysfunction of dopaminergic, GABAergic, and glutamatergic function underlies many core symptoms of schizophrenia. Combined neonatal injection of the N-methyl-D-aspartate (NMDA) receptor antagonist, phencyclidine (PCP), and post-weaning social isolation of rats produces a behavioral syndrome with translational relevance to several core symptoms of schizophrenia. This study uses DNA microarray to characterize alterations in hippocampal neurotransmitter-related gene expression and examines the ability of the sodium channel blocker, lamotrigine, to reverse behavioral changes in this model.Methods:Fifty-four male Lister-hooded rat pups either received phencyclidine (PCP, 10mg/kg, s.c.) on post-natal days (PND) 7, 9, and 11 before being weaned on PND 23 into separate cages (isolation; PCP-SI; n = 31) or received vehicle injection and group-housing (2–4 per cage; V-GH; n = 23) from weaning. The effect of lamotrigine on locomotor activity, novel object recognition, and prepulse inhibition of acoustic startle was examined (PND 60–75) and drug-free hippocampal gene expression on PND 70.Results:Acute lamotrigine (10–15mg/kg i.p.) reversed the hyperactivity and novel object recognition impairment induced by PCP-SI but had no effect on the prepulse inhibition deficit. Microarray revealed small but significant down-regulation of hippocampal genes involved in glutamate metabolism, dopamine neurotransmission, and GABA receptor signaling and in specific schizophrenia-linked genes, including parvalbumin (PVALB) and GAD67, in PCP-SI rats, which resemble changes reported in schizophrenia.Conclusions:Findings indicate that alterations in dopamine neurotransmission, glutamate metabolism, and GABA signaling may contribute to some of the behavioral deficits observed following PCP-SI, and that lamotrigine may have some utility as an adjunctive therapy to improve certain cognitive deficits symptoms in schizophrenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

Gaskin

Toledo-Rodriguez

Alexander

et al. 2016

IJNPPY

View full text Add to dashboard Cite

show abstract

“…Both animal and human studies have reported a clear effect of lamotrigine on memory. In mice, lamotrigine administration positively affected memory acquisition and spatial memory retrieval (Celikyurt et al, 2012). In humans, 14 weeks of lamotrigine treatment in a paediatric BD sample improved working and verbal memory (Pavuluri et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

A single dose of lamotrigine induces a positive memory bias in healthy volunteers

Zghoul,

Hortelano,

Kaltenboeck

et al. 2023

Preprint

View full text Add to dashboard Cite

BackgroundLamotrigine has been shown to be effective in the long-term treatment and relapse prevention of depression in bipolar disorder. However, the neuropsychological mechanisms underlying these effects are unclear. We investigated the effects of lamotrigine on a battery of emotional processing tasks, previously shown to be sensitive to antidepressant drug action in healthy volunteers.MethodsHealthy volunteers (n=36) were randomised in a double blind design to receive a single dose of placebo or 300mg lamotrigine. Mood and subjective effects were monitored throughout the study period and emotional processing was assessed using the Oxford Emotional Test Battery (ETB) 3 hours post administration.ResultsParticipants receiving lamotrigine showed increased accuracy for the recall of positive vs. negative self-descriptors, compared to those in the placebo group. There were no other signficant effects on emotional processing in the ETB, and lamotrigine did not affect ratings of mood or subjective experience.ConclusionsLamotrigine induced a positive bias in emotional memory, similar to the effects of other antidepressants as reported in previous studies. Further work is needed to assess whether similar effects are seen in the clinical treatment of patients with bipolar disorder and the extent to which this is associated with its clinical action in relapse prevention.

show abstract

Predictive validity of a MK-801-induced cognitive impairment model in mice: Implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically

Brown

Rueter

Zhang

2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

Lamotrigine, a mood stabilizer, may have beneficial effects on memory acquisition and retrieval in mice

Cited by 4 publications

References 30 publications

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

A single dose of lamotrigine induces a positive memory bias in healthy volunteers

Predictive validity of a MK-801-induced cognitive impairment model in mice: Implications on the potential limitations and challenges of modeling cognitive impairment associated with schizophrenia preclinically

Contact Info

Product

Resources

About