Background: Invasive breast carcinoma no special type (NST) is the most common type of cancer, making up about 40-75% of invasive breast cancers. Conventional histopathology prognostic indicators including histology type, tumor size, lymph node involvement, grade, hormone receptor expression, etc. still play an important role in the estimated prognosis in breast carcinoma. Tumors bud are an important step in tumor invasion and metastasis and have attracted interest as a marker of prognosis. Research on the role of tumor budding in breast cancer is still limited. Research Objective: Analyzes the correlation between tumors budding and clinicolopathology parameters that include tumor size, lymph node involvement, histological grade, LVI, and immunohistochemical profile in invasive breast carcinoma NST. Material and Methods:This study is an analytical study with a cross sectional approach in 42 samples of paraffin block patients diagnosed histopathologically as invasive breast carcinoma NST. Then, a re-cutting of the paraffin block. Assessment of peritumoral tumor budding is categorized as ≤ 20 buds/10LPB (low grade) and > 20 buds/10LPB (high grade) with H&E staining and 400x enlargement. The correlations between tumor budding index and clinicopathology parameters in invasive breast carcinoma NST was statistically tested. Result: The most age was 50-59 years, with an average age of 52.52 years. There is a significant association between tumor budding index and several clinicopathology parameters, such as grade, LVI,and immunochemical profile. As for tumor size and lymph node involvement did not show a significant association. The most widely found tumor budding index is high grade buds as much as 85.7%. Conclusion: Reporting of tumor budding results in invasive breast carcinoma of NST can be one of the prognostic criteria that can be applied in routine examinations.
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