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Pressures in the intracranial, intraocular, and intravascular spaces are important parameters in assessing patients with a range of conditions, of particular relevance to those recovering from injuries or from surgical procedures. Compared with conventional devices, sensors that disappear by natural processes of bioresorption offer advantages in this context, by eliminating the costs and risks associated with retrieval. A class of bioresorbable pressure sensor that is capable of operational lifetimes as long as several weeks and physical lifetimes as short as several months, as combined metrics that represent improvements over recently reported alternatives, is presented. Key advances include the use of 1) membranes of monocrystalline silicon and blends of natural wax materials to encapsulate the devices across their top surfaces and perimeter edge regions, respectively, 2) mechanical architectures to yield stable operation as the encapsulation materials dissolve and disappear, and 3) additional sensors to detect the onset of penetration of biofluids into the active sensing areas. Studies that involve monitoring of intracranial pressures in rat models over periods of up to 3 weeks demonstrate levels of performance that match those of nonresorbable clinical standards. Many of the concepts reported here have broad applicability to other classes of bioresorbable technologies.

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Graphene-based carbon nanostructures with nanometer dimensions have been of great interest due to the existence of a bandgap. So far, well-ordered edge structure and uniformly synthesized graphene quantum dots (GQDs) with a hexagonal single-crystalline structure have not been directly observed owing to the limited precision of current synthesis approaches. Herein, we report on a novel approach not just for the synthesis of the size-controlled single-crystalline GQDs with hexagonal shape but also for a new discovery on constructing 2D and 3D graphene single crystal structures from d-glucose via catalytic solution chemistry. With size-controlled single-crystalline GQDs, we elucidated the crucial role of edge states on luminescence from the correlation between their crystalline size and exciton lifetime. Furthermore, blue-emissive single-crystalline GQDs were used as an emitter on light-emitting diodes and exhibit stable deep-blue emission regardless of the voltage and doping level.

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Objectives: To compare the outcomes of medial and lateral underlay endoscopic type I tympanoplasty for anterior tympanic membrane (TM) perforations. Study Design: Retrospective chart review. Setting: Tertiary care academic referral center. Patients: Patients who were diagnosed with either chronic otitis media with dry and stable anterior TM perforations or traumatic anterior TM perforations and underwent endoscopic type I tympanoplasty between 2017 and 2019. Interventions: Medial or lateral underlay type I endoscopic tympanoplasty. Main Outcome Measures: Patient demographics, size, and location of TM perforation, graft success rate, and hearing outcome.Results: Of the 170 patients, 68 and 102 patients underwent the medial and lateral underlay techniques, respectively. Patient demographics were not significantly different between groups, except the middle ear mucosa status. Graft success rates were significantly different between groups

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